Protein Info for GFF2380 in Xanthobacter sp. DMC5

Annotation: GTP 3',8-cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 351 TIGR02666: molybdenum cofactor biosynthesis protein A" amino acids 23 to 351 (329 residues), 363.1 bits, see alignment E=6.3e-113 PF04055: Radical_SAM" amino acids 36 to 199 (164 residues), 114.2 bits, see alignment E=1.1e-36 PF13353: Fer4_12" amino acids 40 to 144 (105 residues), 30.1 bits, see alignment E=8e-11 PF06463: Mob_synth_C" amino acids 205 to 330 (126 residues), 129.5 bits, see alignment E=1.1e-41

Best Hits

Swiss-Prot: 74% identical to MOAA_RHIME: GTP 3',8-cyclase (moaA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03639, molybdenum cofactor biosynthesis protein (inferred from 90% identity to xau:Xaut_1387)

Predicted SEED Role

"Molybdenum cofactor biosynthesis protein MoaA" in subsystem Molybdenum cofactor biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (351 amino acids)

>GFF2380 GTP 3',8-cyclase (Xanthobacter sp. DMC5)
VSDLLRDLIDRPGVAAAQQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMSEHMTFLPKQ
DLLSLEELDRLCSAFVLRGVRKLRLTGGEPLVRRDVMTLFRSLSRHIESGRLDELTVTTN
GSQLARHAADLAACGVKRINVSIDTLDPAKFRAITRWGDLARVLEGVKAAQAAGIRVKIN
AVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSTVREQLAERFT
LTDIAYRTGGPARYVEVKETGGRLGFITPLTHNFCEGCNRVRVTCTGTLYMCLGQEDAAD
LRAPLRASSDDALLHRSIDDAIFRKPKGHDFVIDRKTRQPAVGRHMSTTGG