Protein Info for PS417_12100 in Pseudomonas simiae WCS417

Annotation: amino acid ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 transmembrane" amino acids 20 to 46 (27 residues), see Phobius details amino acids 57 to 80 (24 residues), see Phobius details amino acids 92 to 113 (22 residues), see Phobius details amino acids 134 to 152 (19 residues), see Phobius details amino acids 191 to 212 (22 residues), see Phobius details TIGR01726: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family" amino acids 14 to 111 (98 residues), 97.9 bits, see alignment E=2e-32 PF00528: BPD_transp_1" amino acids 35 to 216 (182 residues), 79.3 bits, see alignment E=1.6e-26

Best Hits

Swiss-Prot: 38% identical to YECS_ECOL6: L-cystine transport system permease protein YecS (yecS) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02029, polar amino acid transport system permease protein (inferred from 98% identity to pfs:PFLU2618)

MetaCyc: 38% identical to cystine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-290 [EC: 7.4.2.12]; 7.4.2.12 [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]

Predicted SEED Role

"amino acid ABC transporter, permease protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U147 at UniProt or InterPro

Protein Sequence (220 amino acids)

>PS417_12100 amino acid ABC transporter permease (Pseudomonas simiae WCS417)
MNYQLNFAAVWRDFPSLLAGLGLGLELALLSIAIGCVIGLMMAFAMLSKHRALRVFASVY
VTVVRNTPILVLILLIYFALPNLGIRLDKIPSFIITLSLYAGAYLTEVFRAGLLNIPKGL
REAGLAIGLGEWRIRAYITVPVMLRNVLPALSNNFISLFKDTSLAAAIAVPELTYYARKI
NVESYRVIETWLVTTALYVAACYLIAMLLRYLEQRLAIRR