Protein Info for GFF2333 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Transaldolase (EC 2.2.1.2)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to FSA_SALEP: Fructose-6-phosphate aldolase (fsa) from Salmonella enteritidis PT4 (strain P125109)
KEGG orthology group: K08314, fructose-6-phosphate aldolase 2 [EC: 4.1.2.-] (inferred from 99% identity to ses:SARI_03548)MetaCyc: 90% identical to fructose-6-phosphate aldolase 2 (Escherichia coli K-12 substr. MG1655)
4.1.2.-
Predicted SEED Role
"Transaldolase (EC 2.2.1.2)" in subsystem Folate Biosynthesis or Fructose utilization or Pentose phosphate pathway (EC 2.2.1.2)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- formaldehyde assimilation II (assimilatory RuMP Cycle) (9/9 steps found)
- pentose phosphate pathway (8/8 steps found)
- Rubisco shunt (9/10 steps found)
- pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
- formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
- Bifidobacterium shunt (12/15 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Fructose and mannose metabolism
- Lysine degradation
- Naphthalene and anthracene degradation
- Pentose phosphate pathway
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Tyrosine metabolism
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.2.1.2, 4.1.2.-
Use Curated BLAST to search for 2.2.1.2 or 4.1.2.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (220 amino acids)
>GFF2333 Transaldolase (EC 2.2.1.2) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MELYLDTANVAEVERLARIFPIAGVTTNPSIVAASKESIWDVLPRLQNAIGEEGTLFAQT MSRDAKGMVEEAKRLNNAIPGIVVKIPVTAEGLAAIKLLKKEGIVTLGTAVYSASQGLLA ALAGAKYVAPYVNRVDAQGGDGIRMVQELQTLLEHHAPDSMVLAASFKTPRQALDCLLAG CQAITLPLDVAQQMLNTPAVESAIEKFEQDWKNAFGNLNL