Protein Info for GFF2328 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: '5'-nucleotidase (EC 3.1.3.5)' transl_table=11

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00149: Metallophos
  • amino acids 24 to 252 (229 residues), 45.8 bits, E=9.9e-16
• PF02872: 5_nucleotid_C
  • amino acids 330 to 476 (147 residues), 141 bits, E=3.4e-45

Best Hits

KEGG orthology group: None (inferred from 99% identity to sek:SSPA3674)

Predicted SEED Role

"5'-nucleotidase (EC 3.1.3.5)" in subsystem Purine conversions (EC 3.1.3.5)

MetaCyc Pathways

• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• NAD salvage pathway III (to nicotinamide riboside) (2/3 steps found)
• adenosine nucleotides degradation II (3/5 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• guanosine nucleotides degradation I (2/4 steps found)
• guanosine nucleotides degradation II (2/4 steps found)
• guanosine nucleotides degradation III (2/4 steps found)
• ureide biosynthesis (4/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• NAD salvage (plants) (5/11 steps found)
• superpathway of purines degradation in plants (10/18 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.5

Use Curated BLAST to search for 3.1.3.5

Protein Sequence (518 amino acids)

>GFF2328 '5'-nucleotidase (EC 3.1.3.5)' transl_table=11 (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKVKLLAAGILFTLPFWACAKDVTIIYTNDLHAHVEPYKVPWIADGKRDIGGWANITTLV
KQEKAKNKATWFFDAGDYFTGPYISSLTKGKAIIDILNTMQYDAATIGNHEFDHGWDNTL
LQLSRAKFPIVQGNIFYEDSSKSFWDKPYTIVEKDGVKIGVIGLHGVFAFNDTVSAATRV
GIEARDEIKWLQRYIDELKGKVDLTVALIHEGTPARQSSMGNTDVRRALDKDIQTASQVK
GLDILITGHAHVGTPEPIKVGNTLILSTDSGGIDVGKLVLDYKEKPHHFTVKNFELKTIF
ADEWKPDPQTKQVIDGWNKKLDKVVQQTVAQSPVELTRAYGESSSLGNLAADALLFTAGK
DTQLALTNSGGIRNEIPAGAVTMGAVISTFPFPNELVTMDLTGKQLRSLMEHGAGLSNGV
LQVSKGLEMKYDSSKPIGQRVTVLTLNGKPIDDATVYHIATNSFLADGGDGFAAFTEGQA
RNTSGGYYVSNAIVDYFKAGNTITDEQLKGMRVADVKK