Protein Info for GFF2325 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Small-conductance mechanosensitive channel

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 25 to 45 (21 residues), see Phobius details amino acids 65 to 88 (24 residues), see Phobius details amino acids 96 to 125 (30 residues), see Phobius details PF05552: MS_channel_1st_1" amino acids 16 to 64 (49 residues), 45.6 bits, see alignment 1.1e-15 PF21088: MS_channel_1st" amino acids 72 to 112 (41 residues), 32.6 bits, see alignment 1.3e-11 PF00924: MS_channel_2nd" amino acids 114 to 180 (67 residues), 71.9 bits, see alignment E=7.7e-24 PF21082: MS_channel_3rd" amino acids 187 to 268 (82 residues), 60.3 bits, see alignment E=4e-20

Best Hits

Swiss-Prot: 56% identical to MSCS_EDWI9: Small-conductance mechanosensitive channel (mscS) from Edwardsiella ictaluri (strain 93-146)

KEGG orthology group: None (inferred from 99% identity to sed:SeD_A4503)

MetaCyc: 54% identical to small conductance mechanosensitive channel MscS (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-86

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF2325 Small-conductance mechanosensitive channel (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MEGFELFPKIKGAIKWMAEHSDSVIHFGWNVVAAIILLFIGKLIARLLSRGLEKLLLRRQ
VDATIVHFFSALVRYITIAFTAVAALGRVGIETSSIIAVIGAAGLAIGLALQGSLSNFAA
GVLLVSLRPFRAGEIVQIGLVIGTVEKVHIFSTTLLTADSKEVVIPNGKIIADNIINYSR
HPYRRIDLIIGVDYQSRIADVKNVIHRIIEQDHRIDKTRDITVRLGELAPSSLNFYVRVW
VPNAQYWSTYYDLLENIKEAMDENGINIPYPRMDVRVENVKSITP