Protein Info for GFF232 in Variovorax sp. SCN45

Annotation: Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 21 to 143 (123 residues), 112.1 bits, E=2.6e-36
• PF01276: OKR_DC_1
  • amino acids 149 to 597 (449 residues), 481.6 bits, E=2.9e-148
• PF03711: OKR_DC_1_C
  • amino acids 624 to 748 (125 residues), 155.6 bits, E=1.3e-49

Best Hits

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 86% identity to aav:Aave_3257)

Predicted SEED Role

"Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)" (EC 4.1.1.17, EC 4.1.1.18, EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (15/17 steps found)
• putrescine biosynthesis III (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• cadaverine biosynthesis (1/1 steps found)
• superpathway of polyamine biosynthesis I (6/8 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• superpathway of putrescine biosynthesis (3/4 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (2/3 steps found)
• aminopropylcadaverine biosynthesis (2/3 steps found)
• putrescine biosynthesis II (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• L-lysine degradation I (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• superpathway of ornithine degradation (3/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (4/16 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Glutathione metabolism
• Lysine degradation
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.17 or 4.1.1.18 or 4.1.1.19

Protein Sequence (768 amino acids)

>GFF232 Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18) (Variovorax sp. SCN45)
MKFRFPIVIIDEDFRSENTSGLGIRALAQAIETEGFEVLGVTSYGDLSQFAQQQSRASAF
ILSIDDEEFTVGPDLDPAVLSLRNFIGEVRRKNADVPIYIYGETKTSRHIPNDILRELHG
FIHMFEDTPEFVARHIIREAKSYLEGVQPPFFKALIDYAEDGSYSWHCPGHSGGVAFLKS
PVGQMFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFNADHCFFVTNGTS
TSNKMVWHHTVAPDDVVVVDRNCHKSILHAIIMTGAIPVFMKPTRNHFGIIGPIPKSEFE
QSAIKAKIKANPLLADVDADKVKPRVMTLTQSTYDGVIYNTETIKNMLDGYVDTLHFDEA
WLPHAAFHPFYGAYHAMGKRRVRPKESLVFATQSTHKLLAGISQASHVLVQDSQNRQLDR
DLFNEAYLMHSSTSPQYAIIASCDVAAAMMEPPGGTALVEESILEALDFRRAMRKVEEEF
GKDEWWFKVWGPEKLVDEGIGRAEDWIMHGEKNGPSKSKSKKSPRNWHGFGELADGFNML
DPIKSTIVTPGLDLEGNFAETGIPASVVTKFLAEHGVIVEKTGLYSFFIMFTIGITKGRW
NTLLTALQQFKDDYARNQPMWRILPEFCQQHPGYERLGLRDLCQHIHQLYARYDVARLTT
EMYLSDLTPAMKPSDAFAHIAHRKTERVEIDELEGRITTSLITPYPPGIPLLIPGEVFNK
KIVDYLKFSREFNLQCPGFETDIHGLVARVDETGKKRYYADCVRQTAK