Protein Info for GFF2314 in Sphingobium sp. HT1-2

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 693 transmembrane" amino acids 12 to 28 (17 residues), see Phobius details amino acids 40 to 57 (18 residues), see Phobius details amino acids 64 to 83 (20 residues), see Phobius details amino acids 92 to 110 (19 residues), see Phobius details amino acids 130 to 154 (25 residues), see Phobius details amino acids 166 to 190 (25 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details amino acids 234 to 254 (21 residues), see Phobius details amino acids 260 to 280 (21 residues), see Phobius details TIGR02916: putative PEP-CTERM system histidine kinase" amino acids 11 to 678 (668 residues), 488.9 bits, see alignment E=1.5e-150 PF02518: HATPase_c" amino acids 575 to 680 (106 residues), 76.8 bits, see alignment E=9.1e-26

Best Hits

KEGG orthology group: None (inferred from 74% identity to sjp:SJA_C1-23300)

Predicted SEED Role

"Sensory transduction histidine kinases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (693 amino acids)

>GFF2314 Two-component system sensor histidine kinase (Sphingobium sp. HT1-2)
MSALLQFIGDWGHALAAVLFAALGIFILRRRDDAAEPRMLASALLLTSCWALYVSFGGVD
KPLSGIGESVRNAAWLMLLFVMLRRGPASRGGALVAVGLVYLAVAGLIFLQTSTDLTWRQ
LPVRSDLHQMLVAVSLVLRMMTAIGCLLLVHHLYTAWPSRDRGRVSLLLGALAAMWTYDL
NLYVIGYFAMDRVNELYALRGPLMALLAPVIAIGMRKEMAGRLQLSRTIAFQSLSLVAVG
LYVVVLTAAAVLIEMIAGPYARVVEIGAVFFVAVTALVLLPSPQMRALWKVQVAKHFFQH
RYDYRTEWMRFGETIGRPGENAPPLGERVAKAVADITDSPAALLLLRTDDGRLAFEAQWN
WPQEPIAGLSLPLDQLESWEGSGWIVDVGRIRDGDATFDLPLWLIEDAHVWALVPLLHYG
RLIGAILLAPPPIDRRLDWEDFDMLRAAGRQAATHISEAQGQQALDDAQRFDEFNRRFAF
IAHDIKNLVSQLSLLSRNAERHADNPDFRADMLLTLKESVGKMNDMLARLSQHNKGRPEE
PRPVALGPLVDQVVRSRARQRAITVSGDVPVALADPARVEQILVHLLQNAIDASDADRPV
ELHLGSAHGQATLAVVDQGCGMTAEFIRRDLFKPFSSSKAGGFGLGAFEARSLAEAMGGR
IDVESKPGVGSRFTLRLPLAPAPARDDVQGKAA