Protein Info for GFF2313 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcriptional regulator, IclR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 261 PF09339: HTH_IclR" amino acids 21 to 65 (45 residues), 25.5 bits, see alignment 1.4e-09 PF08279: HTH_11" amino acids 21 to 63 (43 residues), 29.1 bits, see alignment 1.1e-10 PF01614: IclR" amino acids 138 to 255 (118 residues), 63.1 bits, see alignment E=3.7e-21

Best Hits

KEGG orthology group: None (inferred from 52% identity to axy:AXYL_00409)

Predicted SEED Role

"Transcriptional regulator, IclR family" in subsystem Homogentisate pathway of aromatic compound degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (261 amino acids)

>GFF2313 Transcriptional regulator, IclR family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MEANAKQVRSGEGAGIRTRNRTLHILQLFERRTLWTVEAIAAEMGVSISSAYRDVKELSN
LGFLAPSTRSEYMLGPAFIRYDLLMRQGDPLVKAASGPMRELLARTTQHAVVLISRRFRD
QVMCVHQEKGSDHPPSSTYERGVALPMFKGATSKAILANLGDRALKQLYLNHEQEIRESA
GLAGWKDFAKQMKAIRETGFACTDSEVAQGRVGIAAPVFGDGQVVAGVSLVFELARYDEA
GFAAEVRRCAQAISAALETAA