Protein Info for GFF2312 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF02492: cobW" amino acids 9 to 188 (180 residues), 156.7 bits, see alignment E=5e-50 PF07683: CobW_C" amino acids 248 to 339 (92 residues), 82.8 bits, see alignment E=1.3e-27

Best Hits

Predicted SEED Role

"Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (366 amino acids)

>GFF2312 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSSDRVRLPVALLTGFLGSGKTSLLNRWLREPALANAAVVVNEFGDIGIDHNLIASSNDN
TIELSTGCLCCSVQGDLVETLRELLDKRSRGLVRAFDRVVIETTGMADPGPVLQALMTFP
VSNGYRLAQVITTVDGVNGATTLDGFEEATKQVAVADQLIVTKMDLADPPQAQALQQRLQ
ALNPGATVSWATPTQVPCLEVLTELDVYAAATPIPAVRRWLNAEAHADQPARYRPIGAAA
SPHHTEGIETFSLVYDEPLAWQELAAWLDALVLAHGDDLLRVKGILNIAGEARPIVVHAV
QRLFHPPAPLAEWPYEDRRSRLVFITRGLDRAFVEHIFDVIRGRAPSPIPSSTTPLAHKE
NIAWTH