Protein Info for GFF2308 in Variovorax sp. SCN45

Annotation: Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, thiol-disulfide reductase involved in Cu(I) insertion into CoxII Cu(A) center

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 205 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF08534: Redoxin" amino acids 46 to 181 (136 residues), 35.5 bits, see alignment E=1.3e-12 PF00578: AhpC-TSA" amino acids 46 to 168 (123 residues), 51.7 bits, see alignment E=1.3e-17 PF02630: SCO1-SenC" amino acids 49 to 181 (133 residues), 151.8 bits, see alignment E=1.7e-48

Best Hits

KEGG orthology group: K07152, (no description) (inferred from 86% identity to vap:Vapar_4381)

Predicted SEED Role

"Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone" in subsystem Biogenesis of cytochrome c oxidases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (205 amino acids)

>GFF2308 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, thiol-disulfide reductase involved in Cu(I) insertion into CoxII Cu(A) center (Variovorax sp. SCN45)
MNKRNALRLIAGSAGWVGIAATLGLGLSACSEQKQSFNAVDITGADYAKDFSLKDADGKV
RTMADFKGKAVVMFFGYAQCPDVCPTTMTEMAQVKQQLGKDGDKLQVLFVTVDPARDTAE
VLKAYMGAFDPSFVALIPTADELAALAKDYKVYYKKVDGKTPTSYSMDHSAASYVYDTQG
RLRLYARYGAGVPAMVSDLKTLIAS