Protein Info for PS417_11735 in Pseudomonas simiae WCS417
Annotation: methionine gamma-lyase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 78% identical to MEGL_PSEDM: L-methionine gamma-lyase (megL) from Pseudomonas deceptionensis
KEGG orthology group: K01761, methionine-gamma-lyase [EC: 4.4.1.11] (inferred from 94% identity to pfs:PFLU2558)MetaCyc: 78% identical to methionine gamma-lyase (Pseudomonas deceptionensis)
Methionine gamma-lyase. [EC: 4.4.1.11]
Predicted SEED Role
"Methionine gamma-lyase (EC 4.4.1.11)" in subsystem Methionine Degradation (EC 4.4.1.11)
MetaCyc Pathways
- superpathway of branched chain amino acid biosynthesis (17/17 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
- L-methionine degradation II (3/3 steps found)
- dimethyl sulfide biosynthesis from methionine (2/2 steps found)
- seleno-amino acid detoxification and volatilization III (2/3 steps found)
- L-threonine degradation I (4/6 steps found)
- seleno-amino acid detoxification and volatilization I (1/2 steps found)
- superpathway of L-threonine metabolism (12/18 steps found)
- superpathway of seleno-compound metabolism (8/19 steps found)
- hypoglycin biosynthesis (4/14 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.4.1.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See U1TN93 at UniProt or InterPro
Protein Sequence (411 amino acids)
>PS417_11735 methionine gamma-lyase (Pseudomonas simiae WCS417) MNNKHNAFGFSTRAIHHGYDPKDHHGALVPPIYLSATFAFPTAEYGAACFAGEASGHFYT RISNPTLALLESRMATLENGDAAVAFSSGMGAIAATFWTLLRPGDEVIVSQTLYGCTFAL LHHGIGEFGIKVRHVDLTDLTALQAALTPATRMIYCETPANPNLRLVDIAAVAALAHQQP NVTLVVDNTYCTPYLQRPLELGADVVVHSATKYLSGHGDITAGIAVSNQALAQRIRLQGL KDLTGAVMSPQDASLLMRGLKTLALRMDRHCSNAQAVAEALQAHPAVQSVTYPGLRSFPQ YELATQQMKMPGGMIAFELKGGIETGRRFMNALKLFTRAVSLGDAESLAQHPASMTHSTY TPQERAAHGISEGLVRLSVGLEDVADLLADVQQALAKCTRTATRPSKLASF