Protein Info for GFF23 in Xanthobacter sp. DMC5

Annotation: Fosfomycin resistance protein AbaF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 35 to 53 (19 residues), see Phobius details amino acids 59 to 83 (25 residues), see Phobius details amino acids 95 to 113 (19 residues), see Phobius details amino acids 119 to 148 (30 residues), see Phobius details amino acids 165 to 186 (22 residues), see Phobius details amino acids 199 to 219 (21 residues), see Phobius details amino acids 258 to 277 (20 residues), see Phobius details amino acids 285 to 305 (21 residues), see Phobius details amino acids 316 to 334 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 380 to 402 (23 residues), see Phobius details amino acids 408 to 428 (21 residues), see Phobius details PF00083: Sugar_tr" amino acids 24 to 237 (214 residues), 72 bits, see alignment E=7.4e-24 amino acids 248 to 427 (180 residues), 41.9 bits, see alignment E=1e-14 PF07690: MFS_1" amino acids 62 to 382 (321 residues), 102.8 bits, see alignment E=2.9e-33 amino acids 294 to 434 (141 residues), 50.4 bits, see alignment E=2.4e-17 PF13347: MFS_2" amino acids 146 to 362 (217 residues), 37 bits, see alignment E=2.4e-13

Best Hits

KEGG orthology group: None (inferred from 56% identity to bts:Btus_3048)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>GFF23 Fosfomycin resistance protein AbaF (Xanthobacter sp. DMC5)
MAPNPQTSPMSDADLSRHAKRAVLASTVGTMIEWYDFYLYGLVAAIVFGKLYFPSQDPYS
ATLLAFSTFFLGFVARPVGAIIFGHFGDRIGRKGTLVATLMLMGISTVFIGLVPTYEHIG
IWGAVALTVLRVLQGIGVGGEWGGAIAVATEWSKFNRSRGLAASWPQFGSPLGMLLAVGM
LTLTLQMGSTEWFETIGWRIPFLVSALLIFVGLYIRLGVLETPVFQRMQEKKEIAQAPVI
EAVRGFWKEILLTCLMRTGQQAPFVIFTTFLLSYGTSQLGLQKSFLFNCVLVAATLSLFT
TPFFGYLSDRIGRKRMYLIGAFTMMVFAFPYFWLLDTGVPALIVLAILVSLPIHDMQYAP
QAAFIAESFPPSVRYSGSSIGYQLASITSGGPAPIIAAFLLHTYGTSAAISAYIAFIAAI
SFVSTLFLRDRSRDDYTSNAGWVRDDGSVTVHPGASPMAPRAASSPSE