Protein Info for GFF2296 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 39 to 60 (22 residues), see Phobius details amino acids 74 to 105 (32 residues), see Phobius details amino acids 111 to 135 (25 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details amino acids 208 to 232 (25 residues), see Phobius details amino acids 244 to 271 (28 residues), see Phobius details amino acids 287 to 307 (21 residues), see Phobius details PF02653: BPD_transp_2" amino acids 39 to 301 (263 residues), 141.2 bits, see alignment E=1.8e-45

Best Hits

Swiss-Prot: 100% identical to LSRC_SALTY: Autoinducer 2 import system permease protein LsrC (lsrC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K10556, AI-2 transport system permease protein (inferred from 99% identity to stt:t3543)

MetaCyc: 88% identical to Autoinducer-2 ABC transporter membrane subunit LsrC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-454 [EC: 7.6.2.13]

Predicted SEED Role

"Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrC" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (347 amino acids)

>GFF2296 Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrC (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLKFIQNNREATALLAIVCLFVFPGALDSQYLSVQTLTMVFSSAQILMLLAIGATMVMLT
RNIDVSVGSTTGMCAVLLGVMLNAGYSLPVACLATLILGIVAGFFNGVLVAWLKIPAIVA
TLGTLGLYRGIMLLWTGGKWIEGLPAGLKQLSAPVFLGISAIGWFTLVLALLMAWLLAKT
AFGRNFYATGDNLQGARQLGVRTEMVRIMAFSLNGGMAALAGIVFASQIGFIPNQTGTGL
EMKAIAACVLGGISLLGGSGTVIGAILGAYFLTQIDSVLVLLRIPAWWNDFIAGLVLLGV
LVFDGRLRCALQRNLRRQKYARFISPPTPLQTEAKTHAQQNKNKEVA