Protein Info for GFF2295 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: 2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 PF18029: Glyoxalase_6" amino acids 31 to 122 (92 residues), 24.3 bits, see alignment E=4e-09 PF00903: Glyoxalase" amino acids 143 to 258 (116 residues), 59.2 bits, see alignment E=5.6e-20

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>GFF2295 2,3-dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39) (Hydrogenophaga sp. GW460-11-11-14-LB1)
LTGQHPMSMIDPLDLERTFMEIGAHLARLELTASDPAALAGFYARTFGFAVSQQGDAHVC
RAPERELVLRPGDGGQLHLACFRFDTAAALLAHRAQLQARGVALQDVGETAHTVRDPEGR
RIRFEHGPAAPVASTADGLPSARLQHFAVRTPDPAALLAFYTEQLGFVLSDRVRDEAGAI
TAAFLRTDAEHHAMAIFRAPLARFDHFSCEAQDWAALRDWADHMADAGFPLAWGVGRHGP
GNDTFFMLKDMDGNMAEISAELEVCEPGRAVGEWPHQPSTLNRWGVAIMRS