Protein Info for GFF2290 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 PF01557: FAA_hydrolase" amino acids 77 to 282 (206 residues), 231.8 bits, see alignment E=3.8e-73

Best Hits

Swiss-Prot: 43% identical to FAHD2_XENLA: Fumarylacetoacetate hydrolase domain-containing protein 2 (fahd2) from Xenopus laevis

KEGG orthology group: None (inferred from 53% identity to put:PT7_3548)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF2290 Fumarylacetoacetate hydrolase family protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MRLIAFQDESGAARLGARVNDTLLDLTAAGLPDSLDGLLRQGDEGFRAARAAIERGQHAR
PLAGITYLPPVLEPAKAFAIGLNYVDHAAESNFEKPKHPVIFHRYPSSWVAHGQPLVRPH
VSEQFDYEAELVAVIGKGGRYIRKEDALDHVAGYTLFNDGSIRDHQFRSNQWMMGKNFDR
SGGFGPEFVSADELPPGAHGLRLQCRLNGRVVQDANTRDMIFDVATLVAACSEAMALVPG
DLIITGTPAGVGLARKPPLWMKAGDVCEVELEGLGVLSNPVVDER