Protein Info for GFF2279 in Methylophilus sp. DMC18

Annotation: Antiholin-like protein LrgB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 transmembrane" amino acids 19 to 37 (19 residues), see Phobius details amino acids 44 to 62 (19 residues), see Phobius details amino acids 74 to 93 (20 residues), see Phobius details amino acids 104 to 127 (24 residues), see Phobius details amino acids 160 to 181 (22 residues), see Phobius details amino acids 188 to 208 (21 residues), see Phobius details amino acids 215 to 240 (26 residues), see Phobius details PF04172: LrgB" amino acids 25 to 237 (213 residues), 228.9 bits, see alignment E=2.3e-72

Best Hits

KEGG orthology group: None (inferred from 74% identity to mmb:Mmol_0092)

Predicted SEED Role

"LrgA-associated membrane protein LrgB" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (246 amino acids)

>GFF2279 Antiholin-like protein LrgB (Methylophilus sp. DMC18)
MSKRLPIAEIWVYLSGDPLFALIITLASYQLGYLLYVRAKRHPLVNPVAISVLLTCLTID
LLDMPYEKYFEGAQFVHFLLGTATVALAVPIYNGFKRMQGKIFHIWVALTVGSTVSIASA
VAIAKLMGATDNIVGSMYAKSVTAPIAMGIAERLNVSPTLTAVFTVITGMLGAILAPYIL
NAVKVQQWWIRGTAIGVGAHGLGITRAFSVNEEAGVFASMAMGLNGVISAIGLPIVLTYL
RPHLGF