Protein Info for GFF2265 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Rhamnulokinase (EC 2.7.1.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 489 PF00370: FGGY_N" amino acids 7 to 242 (236 residues), 99.4 bits, see alignment E=2.6e-32 TIGR02627: rhamnulokinase" amino acids 7 to 460 (454 residues), 759.8 bits, see alignment E=4.2e-233 PF02782: FGGY_C" amino acids 253 to 440 (188 residues), 117.3 bits, see alignment E=8.4e-38

Best Hits

Swiss-Prot: 100% identical to RHAB_SALTY: Rhamnulokinase (rhaB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00848, rhamnulokinase [EC: 2.7.1.5] (inferred from 99% identity to sed:SeD_A4442)

MetaCyc: 81% identical to rhamnulokinase (Escherichia coli K-12 substr. MG1655)
Rhamnulokinase. [EC: 2.7.1.5]

Predicted SEED Role

"Rhamnulokinase (EC 2.7.1.5)" in subsystem L-rhamnose utilization (EC 2.7.1.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (489 amino acids)

>GFF2265 Rhamnulokinase (EC 2.7.1.5) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MTFRHCVAVDLGASSGRVMLARYDSKHRTLTLREIHRFVNCLQKTDGFDTWDIDSLEKDI
RLGLKKVCNEGILIDSIGIDTWGVDYVLLDKQGQRVGLPVSYRDNRTTGIMPQALVQIGK
SEIYRRSGIQFLPFNTIYQLRALTKQQPELTAQVAHALLMPDYFSYRLTGEMNWEYTNAT
TTQLVNINTDDWDDTLLAWTGAKKSWFGRPSHPGNVIGDWICPQGNRIPVVAVASHDTAS
AVIASPLANKHSAYLSSGTWSLMGFESKMPYTTDEALAANITNEGGAEGRYRVLKNIMGL
WLLQRVLKERRITDLPALIAQTEALPACRFLINPNDDRFINPDDMRAEIQAACRETDQPV
PVSDAELARCIFDSLALLYADILHEQANLRGEKFTQLHIVGGGCQNSLLNQLCADACGIR
VMAGPVEASTLGNIGIQLMTLDELNNVDDFRQVVSANYDLTTYIPNPDSEIARHVAQFQP
KRQTKELCA