Protein Info for GFF2258 in Variovorax sp. SCN45

Annotation: 4-hydroxybenzoate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 29 to 53 (25 residues), see Phobius details amino acids 65 to 85 (21 residues), see Phobius details amino acids 96 to 116 (21 residues), see Phobius details amino acids 122 to 143 (22 residues), see Phobius details amino acids 154 to 178 (25 residues), see Phobius details amino acids 184 to 205 (22 residues), see Phobius details amino acids 267 to 287 (21 residues), see Phobius details amino acids 305 to 325 (21 residues), see Phobius details amino acids 334 to 351 (18 residues), see Phobius details amino acids 357 to 377 (21 residues), see Phobius details amino acids 394 to 418 (25 residues), see Phobius details amino acids 425 to 442 (18 residues), see Phobius details TIGR00895: MFS transporter, aromatic acid:H+ symporter (AAHS) family" amino acids 14 to 416 (403 residues), 442.1 bits, see alignment E=9.3e-137 PF07690: MFS_1" amino acids 36 to 209 (174 residues), 98.9 bits, see alignment E=2.9e-32 amino acids 272 to 437 (166 residues), 47.5 bits, see alignment E=1.3e-16 PF00083: Sugar_tr" amino acids 65 to 228 (164 residues), 77.7 bits, see alignment E=9.1e-26

Best Hits

Swiss-Prot: 58% identical to PCAK_ACIAD: 4-hydroxybenzoate transporter PcaK (pcaK) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>GFF2258 4-hydroxybenzoate transporter (Variovorax sp. SCN45)
MTDTGSIATRRTVDVQWLINARPLSPYQWGIVAMCFLIVLLDGLDTAAMGFIAPALVRDW
GVPSASLGPVMSAALAGMIFGALGSGPLADRFGRKTVLCVSVAVFGGFSLWSAFATGIDQ
LVLLRFLTGLGLGAGMPNATTLLSEYTPEKVKSLLVTTMFCGFNLGMAGGGFLSAAIIPH
WGWHSLLLIGGIVPMLLLPVLLFWLPESARFMVVRGQPVERIRKVLQPVARESLAGVEQF
TIPGQQAGGKGPRGPVLARMFAGGLGPGTLLLWGTNFMGLIIIYLLTSWLPTLMRESGAS
MTQSAVVGALFQFGGVLSAVGVGWAMDRGNPHKVIGICYLLAGVLAVAVGHSMGSGLALV
LLVLLAGMCINGAQSAMPSLAARYYPTHVRATGVSWMLGIGRFGAVLGAWLGAALLGLGW
NFEQVLTVLIVPAVLAMTGVFVKGRISHTDAS