Protein Info for GFF2250 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: formate dehydrogenase formation protein FdhE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 309 TIGR01562: formate dehydrogenase accessory protein FdhE" amino acids 2 to 305 (304 residues), 506.1 bits, see alignment E=2.1e-156 PF04216: FdhE" amino acids 22 to 304 (283 residues), 392.6 bits, see alignment E=8.6e-122

Best Hits

Swiss-Prot: 100% identical to FDHE_SALNS: Protein FdhE (fdhE) from Salmonella newport (strain SL254)

KEGG orthology group: K02380, FdhE protein (inferred from 99% identity to spt:SPA3876)

Predicted SEED Role

"formate dehydrogenase formation protein FdhE" in subsystem Formate hydrogenase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (309 amino acids)

>GFF2250 formate dehydrogenase formation protein FdhE (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNVYNRRAERLRELAENNPLGDYLRFAALI
AHAQEVVLYDHPLEMDLTARIKEANDQGKPPLDIHVLPRDKHWQKLLHSLIAELKPEMSG
PALAVIENLEKASEQELEQMASALFASDFASVSSDKAPFIWAALSLYWAQMASLIPGKAR
AEYGEARQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSRDLHY
WSLENEQAAVKAESCGDCGTYLKILYQEKDPKVEAVADDLASLVLDARMEQEGFARSSIN
PFLFPGEGE