Protein Info for GFF225 in Variovorax sp. SCN45

Annotation: Permeases of the major facilitator superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 398 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 53 to 73 (21 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 106 to 126 (21 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 166 to 186 (21 residues), see Phobius details amino acids 217 to 241 (25 residues), see Phobius details amino acids 253 to 272 (20 residues), see Phobius details amino acids 280 to 299 (20 residues), see Phobius details amino acids 305 to 324 (20 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details PF06779: MFS_4" amino acids 22 to 385 (364 residues), 317.7 bits, see alignment E=1.3e-98 PF07690: MFS_1" amino acids 22 to 335 (314 residues), 39.2 bits, see alignment E=4.3e-14

Best Hits

KEGG orthology group: None (inferred from 88% identity to vpe:Varpa_2846)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (398 amino acids)

>GFF225 Permeases of the major facilitator superfamily (Variovorax sp. SCN45)
MSETGRDRRDAWRAALACMVTLAVAMGLGRFAFTPMLPIMLHEGKLELAGGGVLASLNYL
GYFLGAVSCAAIGVKASTMVRGGLVATAVLLIGMGLLHSFTGWGVLRWAAGVMSAWVFVF
ASGWGLRRLAETNAPTLGGVIYTGPGIGIAMTGLLGGALGRWGSEAGWIGLGLLAFVLIA
VIWRVFDDGQSAAAKSGAPVAVASGAAATGADRNDAIWLVSLYGLAGFGYIITATFLPVI
ARQALPESSWPDYFWPLFGLAIIPGALIGARAPTHWDNRLLLAVAYALQALGVVLSVAWP
TIVGFAFGSLLLGMPFTAITLFAVREARRLRGNAAAGLIGYATASYGVGQIVGPLFAAPL
AQRTGSFQLPLLVAAAALALGSVLFALVWSKSRRLIAV