Protein Info for GFF2219 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HEMN_SALTY: Oxygen-independent coproporphyrinogen III oxidase (hemN) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG orthology group: K02495, oxygen-independent coproporphyrinogen III oxidase [EC: 1.3.99.22] (inferred from 100% identity to sek:SSPA3575)MetaCyc: 93% identical to coproporphyrinogen III dehydrogenase (Escherichia coli K-12 substr. MG1655)
HEMN-RXN [EC: 1.3.98.3]
Predicted SEED Role
"Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 1.3.99.22)
MetaCyc Pathways
- superpathway of heme b biosynthesis from uroporphyrinogen-III (6/6 steps found)
- heme b biosynthesis II (oxygen-independent) (4/4 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.3.99.22
Use Curated BLAST to search for 1.3.98.3 or 1.3.99.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (457 amino acids)
>GFF2219 Coproporphyrinogen III oxidase, oxygen-independent (EC 1.3.99.22) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MSEQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFEDAAFLQAVARYPERPLSLYVHIP FCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIRHRAPLFADRHVSQLHWGGGTPTYLNK AQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQR LVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFTLKRVTELNPDRLSVF NYAHLPTLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQFIGMDHFARPDDELAVA QREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQKELKRYYQQVDERGNALWRG ITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAEDLQLLSPLAKDGLVDISE KGIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI