Protein Info for GFF2217 in Sphingobium sp. HT1-2

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1137 transmembrane" amino acids 15 to 38 (24 residues), see Phobius details amino acids 189 to 212 (24 residues), see Phobius details PF05227: CHASE3" amino acids 47 to 181 (135 residues), 141 bits, see alignment E=5.9e-45 PF13185: GAF_2" amino acids 240 to 373 (134 residues), 50.8 bits, see alignment E=5.2e-17 PF00512: HisKA" amino acids 473 to 540 (68 residues), 68.8 bits, see alignment 8.7e-23 PF02518: HATPase_c" amino acids 587 to 696 (110 residues), 99.4 bits, see alignment E=4.1e-32 PF00072: Response_reg" amino acids 746 to 854 (109 residues), 60.9 bits, see alignment E=3.1e-20 amino acids 868 to 949 (82 residues), 52.5 bits, see alignment 1.3e-17 amino acids 1014 to 1131 (118 residues), 91 bits, see alignment E=1.5e-29

Best Hits

KEGG orthology group: None (inferred from 59% identity to cse:Cseg_3213)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1137 amino acids)

>GFF2217 Two-component system sensor histidine kinase (Sphingobium sp. HT1-2)
MGKAKFGSVSGRTDAWAALGLFLGIAFFLVSGAVAYLNIQGLGESDRAIRHTHNVLIALD
ELLSTAQDAETGQRGYLLTSDRGYLEPYENAVATMPGRLDALARLTRDNPTQQNNLARLR
RHVDAKFAELRETIEARRNQSIIQALTIVTTGRGKQEMDAVRAQLDTMAREELRLREIRL
ADMASASQTAIMSGLVTGLLGVVLTIAVYLLVRRNSKARARQAWLQAGHLGLSDAMRGDQ
SVEQLGEAILAFLARYLGFQGGALFKGEEGQFNRVATLGVPADADMPQRFVAKEGLLGQV
AAEGRAQLLHDVPDHYLTIGSAFGRDRPRHLLIVPTVTDGVVNAVLELGAFDPVDDRVLE
LLEEASAGMGIALRSARFRARLQDALEETQRQAEELQAQGEELRANNDELETQSRQLQDS
ASRLEAQQSELEQTNVQLEEQARHMQAQRDDLARAQLSLQQQAAELDQASRYKSEFLANM
SHELRTPLNSLLIMARLLAENRAGNLSADQVRHAETIETSGNDLLTLINDILDISKIEAG
KLELQPRSVRIAPMLDKLQAIFAPSAQAKGLSFRLAAGADPVEIETDPQRVEQVLKNFLS
NAIKFTDRGEVALTVGRHADGRVAFTVQDSGVGIAEAQQKLIFEPFRQADGTISRKYGGT
GLGLSISRELARLLGGELRVESQPGEGSAFSLLLPDRFDPALSHLPSISLAEAPRPQPVA
PARPRVASLVDTQDDRETLSGDSRLILIVEDDPVFARILCDIAHEQGFQCLIAGTADEGA
LMARQYLPHAVILDMNLPDHTGLSVLDRIKRDMRTRHIPVHVVSVDDDSQAALASGAIGY
LFKPVKRDALIDMLEGLEARMAQRMRRVLVVEDDAQQAESIKLLLASREVETLEAHSAAQ
CFEMLGRETFDCMVLDLNLPDASGFDLLERLSADDSVGFPPVIVYTGRDLGAEEELRLRR
YSKSIIVKGAKSPERLLDEVTLFLHQVVSELPEPQQQLIARSLSRDEALEGKNILVVEDD
IRNVYALTSIFEPHGVHVRIARNGREALVALEEAARADAPKVDLVLMDVMMPEMDGLTAM
REIRKQGWGVGLPIIALTAKAMAQDQQECLAAGANDYLAKPLDVDKLLSLVRVWMPR