Protein Info for GFF2212 in Pseudomonas sp. DMC3

Annotation: Toluene efflux pump membrane transporter TtgB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1054 transmembrane" amino acids 10 to 28 (19 residues), see Phobius details amino acids 339 to 359 (21 residues), see Phobius details amino acids 366 to 389 (24 residues), see Phobius details amino acids 395 to 415 (21 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 470 to 493 (24 residues), see Phobius details amino acids 539 to 557 (19 residues), see Phobius details amino acids 877 to 895 (19 residues), see Phobius details amino acids 902 to 922 (21 residues), see Phobius details amino acids 929 to 952 (24 residues), see Phobius details amino acids 974 to 994 (21 residues), see Phobius details amino acids 1005 to 1029 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1031 (1031 residues), 1362.6 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1050 (1050 residues), 1846.8 bits, see alignment E=0 PF03176: MMPL" amino acids 340 to 497 (158 residues), 35.2 bits, see alignment E=1.1e-12 amino acids 841 to 1035 (195 residues), 20.6 bits, see alignment E=3e-08 PF02355: SecD_SecF_C" amino acids 881 to 1023 (143 residues), 21.1 bits, see alignment E=2.7e-08

Best Hits

Swiss-Prot: 86% identical to TTGB_PSEPK: Probable efflux pump membrane transporter TtgB (ttgB) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 65% identity to abo:ABO_0964)

MetaCyc: 66% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"Multidrug efflux RND transporter MexD" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1054 amino acids)

>GFF2212 Toluene efflux pump membrane transporter TtgB (Pseudomonas sp. DMC3)
MSKFFIDRPIFAWVIALVIMLVGALSILKLPINQYPSIAPPAIAIQVTYPGASAQTVQDT
VVQVIEQQLNGIDNLRYVSSESNSDGSMTITATFEQGTNSDTAQVQVQNKLNLATPLLPQ
EVQQQGIRVTKAVKNFLLVIGVVSRDGSMTKDDLSNYIVSNMQDPISRTAGVGDFQVFGA
QYAMRIWLDPAKLNNFNLTPVDVKNAIAAQNVQVSSGQLGGLPAVQGQQLNATIIGKTRL
QTAEQFKEILLKVNKDGSQVRLKDVAEVGLGGENYAISAQFNGSPASGLAVKLANGANAL
DTAKALRNTIDSLKPFFPQGMEVVFPYDTTPVVTESIKGVVHTLVEAIALVFLVMFLFLQ
NFRATVITTMTVPVVLLGTFGILAAAGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM
SEEGLSPKEATKKSMGQIQGALVGIALVLSAVLLPMAFFSGSTGVIYKQFSITIVSAMAL
SVLVALIFTPALCATMLKPIPKGEHGTPKKGFFGWFNRNFDRGVRSYERGVGNMLTRKAP
YLLAYLLIVVGMIWLFTRIPTAFLPEEDQGVLFAQVQTPAGSSAQRTQVVVDEMREYLLR
PNKDGGEADAVASVFTVTGFNFAGRGQSSGMAFIMLKPWGERNADNSVFNLAARAQQHFF
SFRDAMVFAFAPPAVLELGNATGFDVFLQDRAGIGHEKLMEARNQFLGMAAQSKVLTQVR
PNGLNDEPQFQLEIDDEKASALGITISDINNTLSIALGSSYVNDFIDRGRVKKVYVQGQP
DSRMSPEDLKKWYVRNAEGTMVPFSAFAKGEWVYGSPKLARYNGVEAVEVLGAPAPGYST
GEAMAEVEAIAKKLPSGVGISWTGLSYEERLSGSQAPALYALSLLMVFLCLAALYESWSI
PIAVMLVVPLGIIGALMATSLRGLSNDVYFQVGLLTTIGLAAKNAILIVEFAKELHEQGR
SLREAAIEACRMRLRPIIMTSLAFVLGVVPLAISTGAGSGSQHAIGTGVIGGMLTATILA
IFWVPLFFVTVSSIGQRKKTDADETTETPKEAGQ