Protein Info for GFF2200 in Methylophilus sp. DMC18

Annotation: Multidrug resistance protein MdtC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1023 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 333 to 351 (19 residues), see Phobius details amino acids 358 to 378 (21 residues), see Phobius details amino acids 384 to 408 (25 residues), see Phobius details amino acids 429 to 449 (21 residues), see Phobius details amino acids 461 to 479 (19 residues), see Phobius details amino acids 519 to 537 (19 residues), see Phobius details amino acids 845 to 868 (24 residues), see Phobius details amino acids 875 to 895 (21 residues), see Phobius details amino acids 904 to 927 (24 residues), see Phobius details amino acids 950 to 970 (21 residues), see Phobius details amino acids 979 to 1004 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1005 (1002 residues), 783 bits, see alignment E=4.4e-239 PF03176: MMPL" amino acids 357 to 487 (131 residues), 24.9 bits, see alignment E=9.7e-10

Best Hits

KEGG orthology group: None (inferred from 58% identity to pna:Pnap_2967)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1023 amino acids)

>GFF2200 Multidrug resistance protein MdtC (Methylophilus sp. DMC18)
MNFSAWSIRNPVPAILLFVVLSFLGLKSLNQLGKQNFPDIELPVISVSATLEGAAPPQLE
TEVARKIEDKIATIGGIEHMTTKITDGSVSISVQFTIDTNSEEALNLVRNAVDSARSELP
AAVLTPTVSKVTTSGSAILTFVASADNMDEGELSWFVDNEVSKAMLAVNGVGKITRTGGV
DREVQVNLDPTLMAGLGVNVSDVSAQLKRVQQDASGGRGDIGDNIQSVRTLGALHSADEV
RNLDIPIGDGRHIKLSQVAEVIDTYAERTTYASYDSKPVIRFEITRSKGTSEVTVAKDVR
AALEKFRVLHPQVKIVEAFNMVKPVEDNYHGSMQLLYEGALLAILVVWWFLRDWRATIIA
AVALPLSMIPTFAFMQYFGFSLNILTLLAMALVVGILVDDAIVEIENIVRHLRMGKSPYQ
AAMEAADEIGFAVIATTFTLVAIFLPTAFMGGIPGKFFKQFGITAAIAIMGSLVVARLLT
PMMSAYLLKPHPVKEEQISGFMRAYLRSVEWCLRHRKTVVLAFVLFIVGSLSLMPLLPKG
FVPSSDSSQTKVNIELQPGTALEQTREVVSLAEQIVKQHPEVKAVFSAAGTASTGGGGPN
ASQNSTDVRKGSLVISLTDRSERHQKQSEIEAELRERLKALPGARVNVGIGESGEKLQIT
LASDDGIALGNASQQLEQQLRTLSGVGNITSSASLQRPEVQIIPDIDKAAELGVTVESIA
QVIRIATSGDFSNTMPKLNLPQRQVPIRVRLGSSVRTSLQEIAQLRVPARNGSVSLETVA
TVRMGSGPQQIDRMDRMRNVTFDIELNKRQIGEVMREVQQLPAMQSLPPSVKQLESGDAK
RMNELFASFGGAMVIGVMCIYVVLVLLFGDFLQPVTILGALPLSLGGAFFALLVTHNSFS
MPSVIGLLMLMGVVTKNSILLVEYTIMARKERQLSRFDAIIDGCHKRARPIVMTTIAMAA
GMLPIALGWSADPSFRAPMAITVIGGLITSTVLSLVVIPVLYTYVDDLLGWLRGVSSWLK
KHA