Protein Info for GFF2181 in Methylophilus sp. DMC18

Annotation: Peptidoglycan glycosyltransferase MrdB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 43 to 61 (19 residues), see Phobius details amino acids 73 to 92 (20 residues), see Phobius details amino acids 131 to 152 (22 residues), see Phobius details amino acids 157 to 175 (19 residues), see Phobius details amino acids 180 to 199 (20 residues), see Phobius details amino acids 220 to 238 (19 residues), see Phobius details amino acids 268 to 289 (22 residues), see Phobius details amino acids 301 to 328 (28 residues), see Phobius details amino acids 334 to 353 (20 residues), see Phobius details TIGR02210: rod shape-determining protein RodA" amino acids 14 to 359 (346 residues), 430.5 bits, see alignment E=2.5e-133 PF01098: FTSW_RODA_SPOVE" amino acids 19 to 360 (342 residues), 345 bits, see alignment E=2.5e-107

Best Hits

Swiss-Prot: 51% identical to RODA_HAEIN: Peptidoglycan glycosyltransferase MrdB (mrdB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K05837, rod shape determining protein RodA (inferred from 68% identity to meh:M301_2606)

Predicted SEED Role

"Rod shape-determining protein RodA" in subsystem Bacterial Cytoskeleton or Peptidoglycan Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (365 amino acids)

>GFF2181 Peptidoglycan glycosyltransferase MrdB (Methylophilus sp. DMC18)
MIKQWIGHFIRHIDSILLATVLMVLVVALMVLYSASGQSLLKVNAQLINILVMMGVMFLV
ANTQPQHIERIALPAYLFGLALLIAVALVGDISHGARRWLNLGVTKIQPSELMKLAVPIM
LSWYFSKRESLLRTTDYVVAGVILLVPVLLIAKQPDLGTATLVFAAGFYVIFLAGLSWKF
IFGSAIAFGAALPILWSMLHDYQRRRVEILIDPSQDPLGAGYHIIQATIAIGSGGMTGKG
WLNGTQSQLDFVPERTTDFIFAVFAEEFGLVGCSLLLLLFAIIIGRAFIIASQAKSTFSR
LLAGSIAATFFTYCFVNMGMVSGILPVVGIPLPLVSYGGTSLLTLGLSLGLLMSVQSHKR
LVATD