Protein Info for GFF2167 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: NAD-dependent aldehyde dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 TIGR03250: putative phosphonoacetaldehyde dehydrogenase" amino acids 13 to 484 (472 residues), 888.8 bits, see alignment E=3.8e-272 PF00171: Aldedh" amino acids 28 to 479 (452 residues), 479.7 bits, see alignment E=4.1e-148

Best Hits

Swiss-Prot: 57% identical to PHNY_RHIME: Phosphonoacetaldehyde dehydrogenase (phnY) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 82% identity to vpe:Varpa_2144)

MetaCyc: 57% identical to phosphonoacetaldehyde dehydrogenase (Sinorhizobium meliloti 1021)
1.2.1.-

Predicted SEED Role

"NAD-dependent aldehyde dehydrogenases"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>GFF2167 NAD-dependent aldehyde dehydrogenases (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNARSPLRDSEHFRAEALRIGGERISRERTLDVINPYSRERVGTVPLATLDDVRRAYHIA
HGYQAQLTRYERSSILQKASALLRARAEEASTLITLESGLCKKDSMYEIGRVADVLVFGA
NEALRDDGQVFSCDLTPHGKKRKVITMREPLQGVITAITPFNHPMNQVAHKVVPSIATNN
RMVLKPSEKVPLSAYFLADILYEAGLPPEMFQVVTGDPREIADEMLVNEHVDLITFTGGV
PIGKYIAQKAGYRRIVLELGGNDPLIVMEDADLDKASDLAVQGSYKNSGQRCTAVKRMLV
QASVAAEFTELVVEKTRRWQHGDPMDGAMDMGTVIDAQAAERFQALVNDAVSQGARLLTG
NQREGALYAPTVLDNVRPEMTLVREETFGPVSPIIAFRDIDEAIRISNGTAYGLSSGICT
NRMDHATRFAKELVVGTVNVWEVPGYRIELTPFGGIKDSGLGYKEGVQEAMKSFCNGKTF
TLPW