Protein Info for GFF2103 in Xanthobacter sp. DMC5

Annotation: Cobalt-zinc-cadmium resistance protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1043 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 131 to 151 (21 residues), see Phobius details amino acids 338 to 355 (18 residues), see Phobius details amino acids 361 to 383 (23 residues), see Phobius details amino acids 442 to 462 (21 residues), see Phobius details amino acids 474 to 497 (24 residues), see Phobius details amino acids 531 to 553 (23 residues), see Phobius details amino acids 855 to 874 (20 residues), see Phobius details amino acids 881 to 903 (23 residues), see Phobius details amino acids 909 to 928 (20 residues), see Phobius details amino acids 959 to 978 (20 residues), see Phobius details amino acids 990 to 1015 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1016 (1016 residues), 760.7 bits, see alignment E=1.2e-232 PF00873: ACR_tran" amino acids 8 to 1012 (1005 residues), 816.9 bits, see alignment E=3.6e-249 PF02355: SecD_SecF_C" amino acids 339 to 493 (155 residues), 20.6 bits, see alignment E=3.8e-08

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 70% identity to met:M446_3471)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1043 amino acids)

>GFF2103 Cobalt-zinc-cadmium resistance protein CzcA (Xanthobacter sp. DMC5)
MFTVLVTQSLRNRLLVLALAVVLVVYGAYAVTRLPVDVLPDLNRPTVTIMTEAEGLAPAE
VEQLVTFPLETAVNGLPGLIRLRSASGVGLSVVYAEFDFGTDIFRNRQQIAERLALVRDR
LPANVSPQMGPISSIMGQILMFALISDIASPMAVREAADFVIRPRLLAIPGVAQVIPMGG
EVRQFRVAPDLAAMRAYGITLDGLEKALQQFGSNSGGGFADQNGREFLIRNIARTLSLDD
LKNLVLPRPAGGNVFLHQIAQVDYAARLKRGDAGYMGRPAVILSVEKQPEADTLALTRAV
EELVADLNRSLPDGIRISPPVFRQADFIAASIGNVEKVLMEAMAVVAVVLFLFLLNWRTT
FISLTAIPVSILITAIVFHAFGLSINTMTLGGLAIAIGELVDDAVVDVENIFRRLRENAA
AAAPRPVFDVVVAASREVRSGIVYATLIIVLVFVPLFALPGIEGRLFAPLGQAYIVSILA
SLLTSVTLTPVLAFYLLPALSRHAERDGALVRLLKRGYAALLSTAFRHQRLVMGTTALLF
VAALGATAGLPRAFLPPFNEGSLTISMSFRPGLSLAESHRMGLMAEKIILEVPEVKAVGR
RTGRAELDEHAEGVHASEIEVDLQPSVRSRADITADIRDRLSVLPASFNVGQPISHRLDH
MLSGVRAEIALKLFGDDLDTLRTTAETLRQRLAAIPGLADLQVERQVRVPEVTVRVDYGR
AALYGLQPAQATDALARLSNGRVVSTLVGGNRRFDLIVRLPDATRSADGLAGLLVETPSG
WVPLSQVADVKETDGPNQILREGGRRRIVVLANTAEGRDTAAIIADMRHVIAATDLPPGI
SASLEGTFTAQEASMRTIGGLAAVSLLLVFAILYSRYRSALFALVIMGSVPLALIGAVTA
LWLAGQPLSVASMIGFVTLTGIAARNGILKISHIINLAISEGLPFGPALVMRGSLERLTP
VLMTATSAAIALLPLMSGAEVPGKEILHPVAITIFGGLVSATLLDAVLTPVLVLAYGRRP
LERLVVVTDEASPLADAARADAF