Protein Info for GFF203 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A (1.17.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02963: xanthine dehydrogenase, small subunit
  • amino acids 17 to 482 (466 residues), 587.2 bits, E=1.1e-180
• PF00111: Fer2
  • amino acids 20 to 65 (46 residues), 28 bits, 3.5e-10
• PF01799: Fer2_2
  • amino acids 93 to 170 (78 residues), 92.4 bits, E=3e-30
• PF00941: FAD_binding_5
  • amino acids 204 to 374 (171 residues), 147.2 bits, E=8.9e-47
• PF03450: CO_deh_flav_C
  • amino acids 382 to 482 (101 residues), 114.6 bits, E=4.3e-37

Best Hits

KEGG orthology group: K13481, xanthine dehydrogenase small subunit [EC: 1.17.1.4] (inferred from 50% identity to reh:H16_A1017)

Predicted SEED Role

"Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A (1.17.1.4)" in subsystem Purine Utilization

MetaCyc Pathways

• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (503 amino acids)

>GFF203 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A (1.17.1.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MLARMSTEISAQTLTILRRGQPVTLRHVAPDRTLLEVLREDLHCTGTKEGCGEGDCGACT
VVLGEAMDGRLEYKAINSCIRLAHSVDGLAVWTVEDLANESGELHPAQEAMVQCHGSQCG
FCTPGFVMSLFGMYQNTDGGQGIDRAQAQADLSGNLCRCTGYRPILDAAQQMGDLPLPEG
CGVNEAATVAALQALRKNKEDGTTYLRPTRLAELLRQRAAHPRAQVVAGCTDVGLWVTKM
HKRFDQVLDVTAVRELRRVEDYPHHIAIGAAVTLTEAYAALVKDRPQLQTFAQRFAGLPV
RNSGTLGGNVANGSPIGDSMPLLIGLGASVVLMRWDAKRGAVAHRELRLEDLYTGYRTNV
MRPDELLAWIKVPRPTAGETFKAYKISKRFDDDISAVCLAIQMTVTDGVVAQVSIGAGGV
AATPARARQTEAALRGRPWTAETVKAGVAALRAEFQPISDMRASAAYRQAVLGNLLQRFW
LESQGLQHINLETLNAATLEALA