Protein Info for PS417_10330 in Pseudomonas simiae WCS417

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 520 PF00989: PAS" amino acids 4 to 111 (108 residues), 37.2 bits, see alignment E=1.1e-12 amino acids 137 to 240 (104 residues), 47.6 bits, see alignment E=6.2e-16 PF08448: PAS_4" amino acids 10 to 118 (109 residues), 32 bits, see alignment E=5.2e-11 amino acids 146 to 252 (107 residues), 43.9 bits, see alignment E=1e-14 TIGR00229: PAS domain S-box protein" amino acids 16 to 119 (104 residues), 39.5 bits, see alignment E=2.7e-14 amino acids 133 to 254 (122 residues), 58.7 bits, see alignment E=3.2e-20 PF13426: PAS_9" amino acids 21 to 115 (95 residues), 30.2 bits, see alignment E=1.8e-10 amino acids 151 to 239 (89 residues), 28.3 bits, see alignment E=7e-10 PF08447: PAS_3" amino acids 27 to 107 (81 residues), 66.4 bits, see alignment E=9e-22 amino acids 160 to 242 (83 residues), 64.4 bits, see alignment E=3.8e-21 PF00512: HisKA" amino acids 287 to 350 (64 residues), 28.9 bits, see alignment E=3.8e-10 PF02518: HATPase_c" amino acids 399 to 507 (109 residues), 76.9 bits, see alignment E=6.8e-25 PF14501: HATPase_c_5" amino acids 400 to 494 (95 residues), 22.5 bits, see alignment E=3.7e-08

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 80% identity to pfo:Pfl01_5710)

Predicted SEED Role

"Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7TWJ6 at UniProt or InterPro

Protein Sequence (520 amino acids)

>PS417_10330 histidine kinase (Pseudomonas simiae WCS417)
MSNEFDRVVDALPGVAFTALADGNVDYVNQGWCAYTGRSANAATGSGWLAAVHPDDLPAT
LNSWREAVRNGEPYRKELRLQQADGGYRWFVSDGKPMRDNHDRIIRWWVVSVDIDEHKRD
KALIAHALAEVSASEDRLSNIINAIPGFVWSAAPDGSVGFVNQRWCDYTGMSLDEARGNG
WARSVHPDDAEQLARYWGALLRSGEAGEYEARLRRFDGDYRWFLVRAVPQRDEWGAVLRW
YGENTDIEDRKRAEMLAASIAVERQLSEETLSKVRSELAHLARVASLSTVTASIAHEVNQ
PLAGIITNASTCLRMLGADPPNVTGALETARRTIRDGNRAAEVINRLRALFSKKCITLEP
VDLNEAAREVIAMLLGELQRNDVKLHPEFADALPTVKADRVQLQQVILNMILNATEAMNT
MTGRSRHLHVTTGLDEHQGVYLAVKDNGNGFDPRDAERLFQAFYTTKTTGMGIGLSISRS
IIERHDGVLWATAHSGPGATFQFALPRMTDQDAGSTKEGM