Protein Info for GFF1965 in Variovorax sp. SCN45

Annotation: Magnesium and cobalt efflux protein CorC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 PF00571: CBS" amino acids 78 to 125 (48 residues), 24.7 bits, see alignment 2.5e-09 amino acids 138 to 187 (50 residues), 30.1 bits, see alignment 5e-11 PF03471: CorC_HlyC" amino acids 207 to 284 (78 residues), 66.1 bits, see alignment E=2.3e-22

Best Hits

Swiss-Prot: 44% identical to CORC_VIBCH: Magnesium and cobalt efflux protein CorC (corC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K06189, magnesium and cobalt transporter (inferred from 99% identity to vpe:Varpa_5420)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>GFF1965 Magnesium and cobalt efflux protein CorC (Variovorax sp. SCN45)
VAEPHPERAPVEREDKRGFLQKLAEFIHPGPDSRDELIETLADAEDNEVIGAESRVMLEG
VLRMADMTAGDVMVAAPRMDVINIDAPFDALLHLIIDTAHSRFPVYEGEKENIIGILLAK
DLLKLQRAPGLNIRALLRPATFVPESKGLNDLLREFRGNRNHLAIVIDEFGRVAGLITIE
DVLEQIVGEIEDEFDIAEDEGDIFGLADHTYRVSGDTPIERVAEAFGIVFDEEQLSEDFD
TIGGLIAHEMGHVPKRGEHHAMGGFDFVVLHTKGGAVRWFKVSPARGGDAAD