Protein Info for GFF1960 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Protease VII (Omptin) precursor (EC 3.4.23.49)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF01278: Omptin" amino acids 31 to 312 (282 residues), 443.9 bits, see alignment E=9.9e-138

Best Hits

Swiss-Prot: 100% identical to PGTE_SALTY: Outer membrane protease E (pgtE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K08477, outer membrane protease E [EC: 3.4.21.-] (inferred from 98% identity to sew:SeSA_A2624)

MetaCyc: 50% identical to DLP12 prophage; omptin family outer membrane protease OmpT (Escherichia coli K-12 substr. MG1655)
Omptin. [EC: 3.4.23.49]

Predicted SEED Role

"Protease VII (Omptin) precursor (EC 3.4.23.49)" (EC 3.4.23.49)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.- or 3.4.23.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (312 amino acids)

>GFF1960 Protease VII (Omptin) precursor (EC 3.4.23.49) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKKHAIAVMMIAVFSESVYAESALFIPDVSPDSVTTSLSVGVLNGKSRELVYDTDTGRKL
SQLDWKIKNVATLQGDLSWEPYSFMTLDARGWTSLASGSGHMVDHDWMSSEQPGWTDRSI
HPDTSVNYANEYDLNVKGWLLQGDNYKAGVTAGYQETRFSWTARGGSYIYDNGRYIGNFP
HGVRGIGYSQRFEMPYIGLAGDYRINDFECNVLFKYSDWVNAHDNDEHYMRKLTFREKTE
NSRYYGASIDAGYYITSNAKIFAEFAYSKYEEGKGGTQIIDKTSGDTAYFGGDAAGIANN
NYTVTAGLQYRF