Protein Info for GFF1943 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Glycine cleavage system transcriptional activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 293 transmembrane" amino acids 97 to 112 (16 residues), see Phobius details PF00126: HTH_1" amino acids 10 to 68 (59 residues), 80.1 bits, see alignment E=9.4e-27 PF03466: LysR_substrate" amino acids 93 to 285 (193 residues), 130.6 bits, see alignment E=5.6e-42

Best Hits

Swiss-Prot: 60% identical to AMPR_PSEAE: HTH-type transcriptional activator AmpR (ampR) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 68% identity to aaa:Acav_2656)

Predicted SEED Role

"Glycine cleavage system transcriptional activator" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (293 amino acids)

>GFF1943 Glycine cleavage system transcriptional activator (Hydrogenophaga sp. GW460-11-11-14-LB1)
LGIDAMDLPLNALRAFEVSARHLSFTRAAQELNLTQTAVSQHVKNLEQRLGKPLFRRVPR
GLALTDEGMALLPTLVDAFARVSATLESFKGAHKREVLSVGAVGTFAVGWLLPRLREFQA
RHPFVELRLFTNNNRIDLAAEGLDCAIRFGDGQWPGLQTRHLLAAPLAPVCAPALAHRIR
AVADLGCETLLRSYRSDEWAQWFEAAGGRAPLLTGPMFDSSLVLADAAAQGAGVALLPVS
LFTRDLQGGRLVRLFEAEVDVGGYWLTRLKTRRKSAAMKAFQDWLELQAPALA