Protein Info for GFF194 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Glutathione-regulated potassium-efflux system protein KefC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 620 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 31 to 49 (19 residues), see Phobius details amino acids 55 to 74 (20 residues), see Phobius details amino acids 86 to 110 (25 residues), see Phobius details amino acids 116 to 135 (20 residues), see Phobius details amino acids 147 to 170 (24 residues), see Phobius details amino acids 178 to 202 (25 residues), see Phobius details amino acids 214 to 233 (20 residues), see Phobius details amino acids 239 to 258 (20 residues), see Phobius details amino acids 270 to 290 (21 residues), see Phobius details amino acids 296 to 315 (20 residues), see Phobius details amino acids 327 to 347 (21 residues), see Phobius details amino acids 359 to 378 (20 residues), see Phobius details TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 14 to 285 (272 residues), 305 bits, see alignment E=2.7e-95 PF00999: Na_H_Exchanger" amino acids 16 to 374 (359 residues), 196.2 bits, see alignment E=8.2e-62 PF02254: TrkA_N" amino acids 402 to 511 (110 residues), 95.4 bits, see alignment E=2.9e-31

Best Hits

Swiss-Prot: 100% identical to KEFC_SALA4: Glutathione-regulated potassium-efflux system protein KefC (kefC) from Salmonella agona (strain SL483)

KEGG orthology group: K11745, glutathione-regulated potassium-efflux system ancillary protein KefC (inferred from 93% identity to cko:CKO_03334)

MetaCyc: 90% identical to K+ : H+ antiporter KefC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-42

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (620 amino acids)

>GFF194 Glutathione-regulated potassium-efflux system protein KefC (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAE
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGM
TLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGA
FALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLL
AGFLAIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKAL
TLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLS
SGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEA
RERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQG
TAEGKHSGEVADEPEVKPSI