Protein Info for GFF1914 in Variovorax sp. SCN45

Annotation: Guanine deaminase (EC 3.5.4.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02967: guanine deaminase
  • amino acids 21 to 424 (404 residues), 468.6 bits, E=9e-145
• PF01979: Amidohydro_1
  • amino acids 63 to 411 (349 residues), 145.2 bits, E=3.1e-46
• PF07969: Amidohydro_3
  • amino acids 265 to 403 (139 residues), 33.8 bits, E=2.7e-12

Best Hits

KEGG orthology group: K01487, guanine deaminase [EC: 3.5.4.3] (inferred from 91% identity to vap:Vapar_3881)

Predicted SEED Role

"Guanine deaminase (EC 3.5.4.3)" in subsystem Purine Utilization or Purine conversions (EC 3.5.4.3)

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• drosopterin and aurodrosopterin biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.3

Use Curated BLAST to search for 3.5.4.3

Protein Sequence (428 amino acids)

>GFF1914 Guanine deaminase (EC 3.5.4.3) (Variovorax sp. SCN45)
MKKAYRASLLRFDAAGQPLFDEDGLLVVAPDGTGRQRVLDAGSHAAVAPRHPDAHTTHLP
GRILAPGFVDMHIHFPQTDIIGSPSPGLLPWLENYTFPEESRFADPAHSSEVADVFFDEL
LRNGVTTSLTFATSHVASVEAFFEGARRRSLRMITGKVLQDRNSPDGVRDQTEQSLIDSE
ALIRKWHNTDRLGYAITPRFAPASTDAQMRGASELAARYADTWIQSHVAENRDEVTWVRE
LYPKARSYLDVYTGFGLMRERAVYAHCIYLDDTDRALLRDTKTAAAVSPTSNLFLGSGFF
DFGAADRVGYPYGLASDVGGGTSFSPFHTMMAAYYVGREGQTKTGLSIAPSELWWRHTGG
AARALGLDGVIGNLQPGCEADFLVLDPSATPLLARKTKRANTLEEMLFAMIVLGDDRLVE
RTVISQAL