Protein Info for GFF1903 in Pseudomonas sp. DMC3

Annotation: Cation efflux system protein CusC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 499 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 16 to 476 (461 residues), 365.9 bits, see alignment E=1.6e-113 PF02321: OEP" amino acids 71 to 263 (193 residues), 60.8 bits, see alignment E=8.2e-21 amino acids 289 to 474 (186 residues), 80.2 bits, see alignment E=9.3e-27

Best Hits

KEGG orthology group: None (inferred from 90% identity to pfo:Pfl01_0938)

Predicted SEED Role

"Outer membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (499 amino acids)

>GFF1903 Cation efflux system protein CusC (Pseudomonas sp. DMC3)
VPRRINRALLPLSVLALTLALGGCISTQGIAPHGEALAADSLATDAAIAEAAKDAHWPSA
QWWRAFGDAQLDRWIDLAVQGSPSMAMAAARVRQAKAMAGVAEAAEALQINGESTLKRHN
WPTDQFYGPGELANTTTWDNNAALGFSYALDLWGRERNASERAVDLAHVSVAEARLAQLE
LQNNIVRAYIELSLHYAQRDIVAAMLRQQQQILDLAQKRLSGGIGTHFEVSQAETPLPET
HRQLDALDEEIALSRNQIAALAGKGPGAAAQLQRPTLSLAAPLKLPSALPAELLGQRPDV
VASRWQVAAQARGIDVAHGGFYPNVDLVGSLGYMATGGGALEFLTGKKLNYNVGPAISLP
IFDGGRLRGELGEAAAGYDIAVAHYNQTLINALKNISDQLIRRESMDKQQDFAAESVAAA
QKTYDIAMIAYQRGLTDYLNVLNAQTLLFKQQQVQQQVQAARLSAHAELVTALGGGLGAG
DDVPTAEQTQAPKTPALLR