Protein Info for GFF1899 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: L-threonine 3-dehydrogenase (EC 1.1.1.103)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08240: ADH_N
  • amino acids 25 to 136 (112 residues), 106 bits, E=1.4e-34
• PF16912: Glu_dehyd_C
  • amino acids 145 to 338 (194 residues), 61.7 bits, E=1.1e-20
• PF00107: ADH_zinc_N
  • amino acids 177 to 305 (129 residues), 61.3 bits, E=1.4e-20

Best Hits

KEGG orthology group: K00060, threonine 3-dehydrogenase [EC: 1.1.1.103] (inferred from 72% identity to dac:Daci_4519)

Predicted SEED Role

"L-threonine 3-dehydrogenase (EC 1.1.1.103)" in subsystem Glycine Biosynthesis or Threonine degradation (EC 1.1.1.103)

MetaCyc Pathways

• superpathway of L-threonine metabolism (13/18 steps found)
• L-threonine degradation III (to methylglyoxal) (2/3 steps found)
• L-threonine degradation II (1/2 steps found)
• aminopropanol phosphate biosynthesis II (2/4 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.103

Protein Sequence (350 amino acids)

>GFF1899 L-threonine 3-dehydrogenase (EC 1.1.1.103) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MKSLQKPSPAPGLELRDAAVPTPGPGEVLLRVKATGVCGTDLHIDEWTSSYHFMTRALPV
TIGHEFSGEVSACGEGVSGLRPGQLVTVRPSVVCGVCAACQAQDFDTCTTRQGIGVMRHG
AFADWVVAPARNCVPVPAGVDPLVAALAEPLSVSLEAVRTGGVKRGDRVLVLGPGNIGQG
IALFAREAGASQVVVAGHGDAPRMAVLQRLGFNDLIDVAQGGMAQGLAPYLAAGRFDVVI
EATGAAAVIAPALQALKPHGVLVITGIHAAPVPIDLTALVRQHQTLRGSYRAPEAAWPEV
VAFMERHQDLLRHMITHRVPLSEAAQGFALARDRVATKVMVLPDGEWTPA