Protein Info for GFF1882 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Orotate phosphoribosyltransferase (EC 2.4.2.10)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00336: orotate phosphoribosyltransferase
  • amino acids 24 to 208 (185 residues), 177.9 bits, E=7.6e-57
• PF00156: Pribosyltran
  • amino acids 59 to 177 (119 residues), 44.8 bits, E=4.2e-16

Best Hits

Swiss-Prot: 75% identical to PYRE_POLNA: Orotate phosphoribosyltransferase (pyrE) from Polaromonas naphthalenivorans (strain CJ2)

KEGG orthology group: K00762, orotate phosphoribosyltransferase [EC: 2.4.2.10] (inferred from 86% identity to adk:Alide2_0316)

Predicted SEED Role

"Orotate phosphoribosyltransferase (EC 2.4.2.10)" in subsystem De Novo Pyrimidine Synthesis (EC 2.4.2.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.10

Protein Sequence (238 amino acids)

>GFF1882 Orotate phosphoribosyltransferase (EC 2.4.2.10) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MVLDTGAAKAGAPEAALAQEFVQFCVDAGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKLG
RLAQFYAKALVASGIEFDMIFGPAYKGIPLGAAVSIELARLGRNVPFAYNRKEAKDHGEG
GTLVGAPLKGRVLIVDDVMSAGTAARESIALIRAAGATPHAIAIALDRQEKATEVAADGQ
VRDVDHSAVQYVQRELGMQVCTIARLADLLHYLTARAGGEFDSHRERVLAYRQRYGVA