Protein Info for GFF1865 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 651 transmembrane" amino acids 23 to 42 (20 residues), see Phobius details amino acids 54 to 76 (23 residues), see Phobius details amino acids 88 to 113 (26 residues), see Phobius details amino acids 121 to 142 (22 residues), see Phobius details amino acids 158 to 173 (16 residues), see Phobius details PF04321: RmlD_sub_bind" amino acids 295 to 469 (175 residues), 41.1 bits, see alignment E=2.4e-14 PF01370: Epimerase" amino acids 295 to 512 (218 residues), 61.6 bits, see alignment E=1.6e-20 PF02719: Polysacc_synt_2" amino acids 295 to 589 (295 residues), 402.4 bits, see alignment E=2.2e-124 PF16363: GDP_Man_Dehyd" amino acids 297 to 423 (127 residues), 41.8 bits, see alignment E=2e-14

Best Hits

KEGG orthology group: None (inferred from 63% identity to ara:Arad_0395)

Predicted SEED Role

"UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)" in subsystem N-linked Glycosylation in Bacteria (EC 4.2.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.-

Use Curated BLAST to search for 4.2.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (651 amino acids)

>GFF1865 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNNRDHRGQAAATLLHMPRAAKRLTAVLVDIALCALTVWIALCLRQEHWVQLTPAHSLAI
MGAVLIALPLFIRFGLYRAIFRYAGWNAMVSLAQAMALYALFYVTVFTVIGVPGVPRTVG
VIQPLLLLVTVGFSRVVVRYWLGGLYRTMLQREHLPGILIYGAGMAGRQLAAALARGSEQ
RLLGFLDDDDELQGNSLDGRTVYDPAELVQLIPNLGVTDVLLALPSITRQRRLDILDTLR
HLPVHVRTLPGMSDLATGRVTMSDVRELDIEDLLGRDPVTPDTALLHRLIHGKVVAVTGA
GGSIGSELCRQIAACAPHTLLLVENSEFALYQIHRELDALSDTGTPDVQLVPLLASVQDE
ARIGQIMQAWRPDTVYHAAAYKHVPLVEHNPVQGLRNNVWGTWVCARAAQAAGAANFVLI
STDKAVRPTNVMGASKRLAEMVLQALAAEPGSGTTFAMVRFGNVLGSSGSVVPLFREQIR
NGGPITLTHPDITRYFMTIPEAAQLVIQAGAMAQGGDVFVLDMGEPVRIIDLARRMIELS
GLQVKTEQHPTGDIEIHITGLRPGEKLYEELLIGDNPQPTQHARIMKAQEDLLPWDELQT
LLASLEEAMERNDVATVRALLQVCVQGYQPAGEVVDWLHSSPGTPLESARH