Protein Info for GFF1848 in Variovorax sp. SCN45

Annotation: Proteins incorrectly called adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1346 PF00069: Pkinase" amino acids 26 to 278 (253 residues), 161.4 bits, see alignment E=5.9e-51 PF07714: PK_Tyr_Ser-Thr" amino acids 28 to 278 (251 residues), 102.8 bits, see alignment E=4.1e-33 TIGR03903: TOMM system kinase/cyclase fusion protein" amino acids 48 to 1314 (1267 residues), 1318.5 bits, see alignment E=0 PF00211: Guanylate_cyc" amino acids 381 to 506 (126 residues), 31.9 bits, see alignment E=2e-11 PF13191: AAA_16" amino acids 527 to 712 (186 residues), 78.4 bits, see alignment E=1.9e-25

Best Hits

KEGG orthology group: None (inferred from 74% identity to dac:Daci_4365)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1346 amino acids)

>GFF1848 Proteins incorrectly called adenylate cyclase (Variovorax sp. SCN45)
MQDAATNPTQAAASQLAPPPLEIPGYDLEEALGAGGYGTVYRARQRSTGAQVAIKVVKLQ
AGNRRVARFHRETRLCAALHHPHIVQLLDKGEQGDCVYGVFEYVPGETLTSLIRRQGALT
ASETGRLMAEVLDALDCAHAAGIVHRDLKPDNVMVTLTGAVPHAKVLDFGIGTVIPQRTG
LQFPALTMTEESLGTPAYSAPEQLRGEPPSIRTDLYAWGLMFLECLTGAPAVQGASAAEI
LHRQLSPQEIPLPPEIVEHPVAALLRKALKKKASERSDSAATLLAELTRLRLEDLVGVLR
STRQAQHETMTRTVATTRVFSEKRQLTVLCCSVSVWPDTDADGAETRAALPSDIEDIELL
QRDELALFAETATRRGGLLAGTLGDRMIVLFGYPHASDTDARQASMTALELMALSRRRSA
AIAQAHGVHLGIRMGMHTGMAVVANGEVPSGHAVNVAMRLEAVAETGTLLASESSHRLLG
RYAHFDKAANVSLPGQSAGIQTYQLNVDRQAPLLPDPSPDAAALAVCVGRESELQRLRAA
WTRARQDRGSAVWIRGEPGIGKSCLADVLRAHVLAEGLRTVGAQCQPENRNNALTPFLNL
LRQRLDAAPDTSPDGRREQLREILRGAGCDEDAVLPIFCAWLSLPLGDCEPSRISPPMQK
ALLLASMAQWLLHMAESEPLLLVLEDMHWADPTSIEFVEQLSAQLPRCRVLLVFTARPEW
TPPQGLEAECIDVRRLDDAQAAELARRALAPRAVTAGVIRNVVERTDGVPLFVQEMARML
LDAYLVESDGVWGFRDTVQPAAIPVTLRDSLVSRFDRLGPLKNLLQLAATIGRQFEIDLL
CACSGRAREAVDSDMAVLREAELVMPDERAGAGAYMFRHALIRDTAYECMLVAQRRQQHR
DVAQTLVQRYPQRVAAEPGGVAQHWADAGDHAQAVAHAVQQLRITQVRSLNDETIAYARH
IDSWMGQLDGAAQPEARLDVNSYVTQAMMNKYGWAHEQVVERIALSQDLLNDTVAREKQV
QHLWTLITYHHVASNRGEVRRLSQRLLDHATQQQDQGVLVAAQTYLGLAHYSDGRFDLAE
QALTDAIERYDPVAHAHHAAEFGFDTRVWATTGRALVRWFAGHDEAARNDATTAVRLARE
MSHIPSLSMALLYQSLGHQARGDRARALASTGELLDITARYGLPAFTGYAEIIRCWASGE
ASDIARADGAVEALWGMGCRYCQSYYRSFAAETLAAGQRWTEAAERIDECLRLVDVLEER
LYSAELHLKKARYLQAAGADSATVQACFSQAALTARESGKHRTETEALAALQALAPAVHD
VAGRLKELAALRPELSVRTLVHAHIT