Protein Info for GFF1841 in Variovorax sp. SCN45
Annotation: Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 95% identity to vpe:Varpa_4513)Predicted SEED Role
"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)
MetaCyc Pathways
- adenosine nucleotides degradation II (5/5 steps found)
- purine nucleotides degradation I (plants) (10/12 steps found)
- adenosine nucleotides degradation I (7/8 steps found)
- guanosine nucleotides degradation II (4/4 steps found)
- purine nucleotides degradation II (aerobic) (9/11 steps found)
- superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
- guanosine nucleotides degradation I (3/4 steps found)
- guanosine nucleotides degradation III (3/4 steps found)
- inosine 5'-phosphate degradation (3/4 steps found)
- ureide biosynthesis (5/7 steps found)
- superpathway of purines degradation in plants (12/18 steps found)
- purine nucleobases degradation II (anaerobic) (16/24 steps found)
- caffeine degradation III (bacteria, via demethylation) (2/7 steps found)
- caffeine degradation IV (bacteria, via demethylation and oxidation) (2/10 steps found)
- theophylline degradation (1/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.1.4
Use Curated BLAST to search for 1.17.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (822 amino acids)
>GFF1841 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) (Variovorax sp. SCN45) MNKPIDARLLQPAQAFADYLTNTAARIDVGAEALAHERGMRVGISRPHESAHLHVAGEAT YIDDIPELAGTLHCALGLSPAANGRVTALSLDAIRAMPGVVAVITADDIPGTNDCGSIIH DDPILLPVNDGGEIRYLGQPVFAVIAETRDAARRAAAKAKDALTIEAQPPVLTPQAAHER GQYVVPPMHIVRSGGGANEGDEAAVRTAIAKAPRRHKSTLDVGGQEQFYLEGQISYAIPK EGGALHIHCSTQHPSEMQHLVAHAMHLQSNEVHVECRRMGGGFGGKESQSALFACVAAIA ARQLQRPVKLRLDRDDDFMVTGRRHCFWYEYEVGYDDEGRILGAEITMVSRAGHSADLSG PVMTRALCHFDNAYWLPNVSMHGFSGKTNTQSNTAFRGFGGPQGAIAIENIMDSVARELK CDPLDVRRVNFYGKTENNVTPYRQTVTDNIVHELVAELEASSDYRARRDDIAAFNKKSVV LKRGLALAPLKFGISFNVKHFNQAGALVHVYTDGSILVNHGGTEMGQGLNTKVAQVVAHE LGVSFERVRVTATDTTKVANTSATAASTGADLNGKAAQDAARQIRERLADCAAERHGGKP GEVRFANDKVEVNGKTLAFSTVVGEAYLDRKQLWSDGFYATPGLSWDKDKMQGRPFYYYA YGAAVSEVIVDTLTGEWKLLRADILHDAGKSLNPAVDIGQVEGAFIQGMGWLTTEELVWH PQSGKLTTHAPSTYKIPTANDCPPVFNVRLFEGQNFEDSIHRSKAVGEPPLLLPFSVFFA IRDAVSAAGDHRVDPPLKAPATSESILRAVTAVQAGQAASVE