Protein Info for PS417_00910 in Pseudomonas simiae WCS417

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 333 TIGR00229: PAS domain S-box protein" amino acids 40 to 168 (129 residues), 48.8 bits, see alignment E=7.4e-17 PF08447: PAS_3" amino acids 67 to 154 (88 residues), 70.5 bits, see alignment E=1.8e-23 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 168 to 331 (164 residues), 147.1 bits, see alignment E=3.9e-47 PF00990: GGDEF" amino acids 172 to 329 (158 residues), 142.2 bits, see alignment E=1.9e-45

Best Hits

KEGG orthology group: None (inferred from 94% identity to pfs:PFLU0183)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U0P8 at UniProt or InterPro

Protein Sequence (333 amino acids)

>PS417_00910 diguanylate cyclase (Pseudomonas simiae WCS417)
MVHENPYLPDPPTAEHPRPAAAATLLALVHAQGEVERLSEREQLLSSMLVSVNAVLWAMD
WETRRVLYVSPAYERVFGRSAGLLLADHREWRNSIHPEDLDYAEHSLARVLERGAVEDRE
YRIITADGQIRWLSDKCYINQRVEPGEPLIVVGMAEDITEKKQMELELHRLATTDVLTQS
SNRRHFFECANLAFDTACAKGEPLAFLLLDIDDFKDVNDSYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCAPEMALQVAERLGREIQELSFSYEGQAFSVTISQGLAS
LTEADSTLDSLFARADAAMYEAKRLGKNRVVAG