Protein Info for GFF1806 in Variovorax sp. SCN45

Annotation: Na+/H+-dicarboxylate symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 46 to 65 (20 residues), see Phobius details amino acids 77 to 98 (22 residues), see Phobius details amino acids 147 to 169 (23 residues), see Phobius details amino acids 182 to 209 (28 residues), see Phobius details amino acids 221 to 244 (24 residues), see Phobius details amino acids 292 to 319 (28 residues), see Phobius details amino acids 324 to 341 (18 residues), see Phobius details amino acids 352 to 376 (25 residues), see Phobius details amino acids 382 to 403 (22 residues), see Phobius details PF00375: SDF" amino acids 8 to 403 (396 residues), 339 bits, see alignment E=2e-105

Best Hits

Swiss-Prot: 69% identical to DCTA2_RALSO: C4-dicarboxylate transport protein 2 (dctA2) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 94% identity to vpe:Varpa_4565)

MetaCyc: 52% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"sodium:dicarboxylate symporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (447 amino acids)

>GFF1806 Na+/H+-dicarboxylate symporter (Variovorax sp. SCN45)
MPRFAKSLFGQVVIALVLGVLAGLLAPEYAVKLKPLGDGFIKLIKMIIPVLVFCVVVHGI
AGAGDLKRVGRVGVKSLIYFEVLTTIALAMGLVLAFVFQPGAGMNVDPAKLDPAAMSAYA
SNADKLTSGGTVEFLMKLIPTTVVNAFATGDVLQVLLFAVLFGCALTLLGDRGKPVAVVV
DALSLVLFKIMGIIIKLAPLGVLGAIAFTVGQYGIGSLKQLGMLVALFYGAVLIFVFVVL
GLVMRMSGFSLIKLLRYLREELTIVFATTSSDSVLPQVMAKLRRMGIRDSTVGLVIPTGY
SFNLDAFSIYITLAAVFIAQATNTPISMADLLTILAIALVTSKGAHGVPGSAIVVLAATL
HAIPAIPAIGLVLVLSVDWFMGIARALGNLIGNCVATVAIAAWEGDIDRERAHAVLDGNY
APEALDGEPLAEAAPVVNTGTATTAAH