Protein Info for GFF1782 in Variovorax sp. SCN45

Annotation: integral membrane sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 172 to 193 (22 residues), see Phobius details PF00512: HisKA" amino acids 248 to 310 (63 residues), 56.7 bits, see alignment E=2e-19 PF02518: HATPase_c" amino acids 358 to 464 (107 residues), 91.8 bits, see alignment E=4e-30

Best Hits

KEGG orthology group: None (inferred from 52% identity to dac:Daci_3960)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (475 amino acids)

>GFF1782 integral membrane sensor signal transduction histidine kinase (Variovorax sp. SCN45)
MMQALAQRWKNWKQPSLMRRLLLAQMGVVALLWTMAVALLLYDSYEDPELLKYDKIFQTV
LAISQNMADHPDKQQETLAAFDAALLETVGDGDAASDSSPVMQVWQGDRLIYRSTAAVPV
ILNSAPNRIETVKAGNREWRARTLVSATTDTRVMLAEPSVWRLTVTVMYRGYYLLPLVIS
LPFLIFPAWLSVRLALRPWRQVSKETAERGPADLTPLSYTPPHKELQPLVQSINSLLQRV
RDSTSRERSLIADAAHELRTPLAAMRVNVEALKEQSTDEGQRELMGNLLRSNDRAARLVG
QLLQLMRSDAVSDNALPVMLSLDGLVQDRLAMIEGLASARGIELELVCEDRVPVLGERES
LVSMIDNLVNNAIKYSPSGSTVVVHVAHEGPHALLTVADQGPGIPAALRERVFDRFFRNP
DQTQSGSGLGLAIVKSVIDRHGGEVTLGETAEGGLLVTVRLPLAMAEAPQPMLCS