Protein Info for PS417_00895 in Pseudomonas simiae WCS417

Annotation: succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 475 (457 residues), 578.9 bits, E=3.3e-178
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 30 to 474 (445 residues), 768.2 bits, E=1.4e-235

Best Hits

Swiss-Prot: 90% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K14269, glutarate semialdehyde dehydrogenase [EC: 1.2.1.20] (inferred from 98% identity to pfs:PFLU0180)

MetaCyc: 98% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

No annotation

MetaCyc Pathways

• L-lysine degradation IV (5/5 steps found)
• L-lysine degradation X (5/6 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation I (4/7 steps found)
• L-lysine degradation III (2/6 steps found)
• superpathway of L-lysine degradation (17/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20

Sequence Analysis Tools

See A0A1N7UB37 at UniProt or InterPro

Protein Sequence (480 amino acids)

>PS417_00895 succinate-semialdehyde dehydrogenase (Pseudomonas simiae WCS417)
MQLKDAQLFRQQAFIDGAWVDADNGQTLKVNNPATGEILGTVPKMGAAETRRAIEAADKA
LPAWRALTAKERANKLRRWFELLIENQDDLGRLMTLEQGKPLAEAKGEIVYAASFIEWFA
EEAKRIYGDVIPGHQPDKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVIK
PASQTPFSALALVELAHRAGIPKGVLSVVTGSAGDIGGELTSNPIVRKLSFTGSTEIGRQ
LMAECAKDIKKVSLELGGNAPFIVFDDADLDKAVEGAIISKYRNNGQTCVCANRLYIQDS
VYDAFAEKLKVAVAKLKIGNGLEEGTTTGPLIDEKAVAKVQEHIADALKKGATLLAGGKV
MEGNFFEPTILTNVPKDAAVAKEETFGPLAPLFRFKDEAEVIAMSNDTEFGLASYFYARD
LGRVFRVAEALEYGMVGVNTGLISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYLCLGI