Protein Info for GFF1772 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Trimethylamine-N-oxide reductase (EC 1.6.6.9)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details transmembrane" amino acids 384 to 409 (26 residues), see Phobius details TIGR02164: trimethylamine-N-oxide reductase TorA" amino acids 8 to 835 (828 residues), 1535.1 bits, see alignment E=0 PF18364: Molybdopterin_N" amino acids 55 to 95 (41 residues), 59.1 bits, see alignment 4.9e-20 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 56 to 835 (780 residues), 1237.5 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 99 to 572 (474 residues), 275.6 bits, see alignment E=9.4e-86 PF01568: Molydop_binding" amino acids 690 to 811 (122 residues), 88.5 bits, see alignment E=4.8e-29

Best Hits

Swiss-Prot: 100% identical to TORA_SALTY: Trimethylamine-N-oxide reductase (torA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K07811, trimethylamine-N-oxide reductase (cytochrome c) 1 [EC: 1.7.2.3] (inferred from 90% identity to eum:ECUMN_1179)

MetaCyc: 90% identical to trimethylamine N-oxide reductase 1 (Escherichia coli K-12 substr. MG1655)
Trimethylamine-N-oxide reductase (cytochrome c). [EC: 1.7.2.3]; RXN0-5264 [EC: 1.7.2.3]

Predicted SEED Role

"Trimethylamine-N-oxide reductase (EC 1.6.6.9)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 1.6.6.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.6.6.9 or 1.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (850 amino acids)

>GFF1772 Trimethylamine-N-oxide reductase (EC 1.6.6.9) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKNKDSLHVSRRRFLAQLGGLTVAGMLGPSLLTPRSARAADAVAPGAATKEGILTGSHWG
AIRATVVDGRFVAAKPFEQDKYPSKMIAGLPDHVHNAARIRYPMVRVDWMRKGHQSDTSQ
RGDNRFVRVSWDEALDLFYQELERVQKTYGPSALLTASGWQSTGMFHNASGMLARAIALH
GNSVSTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDMVKNQQANW
WCPDHDVYQYYEQLKEKVASGAISVISIDPVVTSTHDYLGRDKVKHIAINPQTDVPLQLA
LAHTLYSEKLYDKNFLDNYCVGFDQFLPYLLGEKDGQPKDAAWAEKLCGIDADTIRALAR
QMAGDRTQIIAGWCVQRMQHGEQWSWMVVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRK
GIILSGFSGSTTVPPVHDSTDYKGYSSTIPIARFMDAILEPGKIINWNGKSVKLPPLKMC
VFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQFG
NHSNRGIIAMKQVVSPQFEARNDFDIFRDLCRRFNREAAFTEGLDEMGWLKRIWQEGSQQ
GKGRGIHLPIFEVFWNQQEYIEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIAD
MQYDDCQGHPMWFEKIERSHGGPGSQRWPLHLQSVHPDFRLHSQLCESETLRQQYAVGGK
EPVFINPQDASARGIRNGDIVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGD
LNALCKYGNPNVLTLDIGTSQLAQATSAHTTLVEIEKYTGPMDNVTAFNGPVEMVAQCEY
VPASQGNPHD