Protein Info for GFF1767 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Sensor protein torS (EC 2.7.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 895 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 316 to 337 (22 residues), see Phobius details TIGR02956: TMAO reductase sytem sensor TorS" amino acids 1 to 789 (789 residues), 1086.2 bits, see alignment E=0 PF21689: TorS_sensor_domain" amino acids 31 to 301 (271 residues), 292.6 bits, see alignment E=1e-90 PF00672: HAMP" amino acids 337 to 388 (52 residues), 28.6 bits, see alignment 4.3e-10 PF00512: HisKA" amino acids 428 to 491 (64 residues), 66 bits, see alignment 7.5e-22 PF02518: HATPase_c" amino acids 539 to 644 (106 residues), 91.2 bits, see alignment E=1.8e-29 PF00072: Response_reg" amino acids 667 to 776 (110 residues), 52.9 bits, see alignment E=1.2e-17 PF01627: Hpt" amino acids 811 to 866 (56 residues), 44.2 bits, see alignment 5.8e-15

Best Hits

Swiss-Prot: 63% identical to TORS_ECO57: Sensor protein TorS (torS) from Escherichia coli O157:H7

KEGG orthology group: K07647, two-component system, OmpR family, sensor histidine kinase TorS [EC: 2.7.13.3] (inferred from 100% identity to stm:STM3826)

MetaCyc: 63% identical to sensor histidine kinase TorS (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensor protein torS (EC 2.7.3.-)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (895 amino acids)

>GFF1767 Sensor protein torS (EC 2.7.3.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MAALTLLSTVIGWISLRVISQVEQTNTQALLPTMNMARQLSEASAYELFSAQNLTNADSE
GVWLAQGKMLKAQSLKINHLLQALSEQGFNTSAIARQEKEIAQTLGQQGTLVGEILTLRA
QQQQLSRQIAEAAESIAAQAHGQANNAATSAGATQAGIYDLIESGKGDQAERALDRLIDI
DLEYVNQMNELRVNALRFKQLIVTLKDAQGLSDAEDTDEKLNQLVKILSRRQQRIEDPTV
RAQIADALETINQYTTLVTLFRKENAIRDQLQTLMANNLFQFTRFSTEVSQLVNAIEKRN
EAGLARLTHASQRGQIGLVILGILALCSLSFILWRVVYRSVSRPLAQQTQALQRLLEGDI
DSPFPEAAGVSELDTISRLMEAFRANVRKLNRHREDLAEQVRSQTAELHALVLEHRQARA
EAEKANEAKSTFLAAMSHEIRTPLYGILGTVQLLADKPLMTNYRDDLQAINDSGESLLAI
LNDILDYSAIEVGGTNVSISEEPFEPRQLLNSALHLMHSRVQVALITDFSEQLPSTLQGD
PRRIRQIVINLLSNAAKFTDRGSIVLRTFCDDQSWFIEVEDTGCGIPEAKLTAIFKPFVQ
ATGRRGGTGLGLAISASLAEAMGGTLTVTSTLHVGSCFRLQLPVCHSKPASKSAFREPIN
LNGLRLLLIEDNMLTQRITAEMLTGKGVKVSLAESANDALRCLAEGESFDVALVDFDLPD
YDGLTLAQQLMSLYPAMKRIGFSAHVIDDNLRQRTAGLFCGIIQKPVPREELYRMIAHYL
QGKSHNARAMLNEHQLAGDMASVGPEKLRQWVALFKDSALPLVEEIEAARAMNDDVNIKR
LAHKLKSGCASLGMTQATEACRELELQPLSDIDIKTIVTQGVTALDAWIAGHPSP