Protein Info for GFF1754 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Chromosomal replication initiator protein DnaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 PF11638: DnaA_N" amino acids 4 to 64 (61 residues), 69.5 bits, see alignment E=4.9e-23 TIGR00362: chromosomal replication initiator protein DnaA" amino acids 6 to 464 (459 residues), 621.3 bits, see alignment E=5.5e-191 PF00308: Bac_DnaA" amino acids 132 to 291 (160 residues), 251 bits, see alignment E=1.8e-78 PF01695: IstB_IS21" amino acids 167 to 269 (103 residues), 33.6 bits, see alignment E=8.9e-12 PF00004: AAA" amino acids 168 to 269 (102 residues), 26.5 bits, see alignment E=2.3e-09 PF08299: Bac_DnaA_C" amino acids 375 to 443 (69 residues), 111.8 bits, see alignment E=3.8e-36

Best Hits

Swiss-Prot: 100% identical to DNAA_SALPA: Chromosomal replication initiator protein DnaA (dnaA) from Salmonella paratyphi A (strain ATCC 9150 / SARB42)

KEGG orthology group: K02313, chromosomal replication initiator protein (inferred from 99% identity to sec:SC3756)

Predicted SEED Role

"Chromosomal replication initiator protein DnaA" in subsystem DNA-replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>GFF1754 Chromosomal replication initiator protein DnaA (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNIN
GLLNTFCGADAPQLRFEVGTKPVTQTLKTPVHNVVAPAQTTTAQPQRVAPAARSGWDNVP
APAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHL
LHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELET
RVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVRE
ALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRSVARPRQMAMALAKELTNHS
LPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS