Protein Info for PS417_08895 in Pseudomonas simiae WCS417
Annotation: 2-oxoglutarate dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 84% identical to ODO1_AZOVI: 2-oxoglutarate dehydrogenase E1 component (sucA) from Azotobacter vinelandii
KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 84% identity to avn:Avin_29770)Predicted SEED Role
"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)
MetaCyc Pathways
- 2-oxoglutarate decarboxylation to succinyl-CoA (3/3 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Lysine degradation
- Tryptophan metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.4.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1N7TZS8 at UniProt or InterPro
Protein Sequence (943 amino acids)
>PS417_08895 2-oxoglutarate dehydrogenase (Pseudomonas simiae WCS417) MQESVMQRMWNSGYLSGGNAAYVEELYELYLHDPNAVPEEWRTKFQTLSSDGNAATDVSH ATIRDQFVLLAKNQRRAQPVSAGSVSSEHEKKQVEVLRLIQAYRMRGHQAAQLDPLGLWK RPAPADLSINHYGLTNADLDTTFRAGDLFIGKEEASLREIHEALQQTYCRTIGAEFTHIT DSEQRHWFQHRLEGVRGRPVLSADVRSHLLERVTAAEGLEKYLGTKYPGTKRFGLEGGES LIPMLDELIQRSGSYGTKEIVIGMAHRGRLNVLVNTFGKNPRELFDEFEGKKKVELGSGD VKYHQGFSSNVMTTGGEVHLAMAFNPSHLEIVSPVVEGSVRARQDRRNDTTGEKVLPISI HGDAAFAGQGVVLETFQMSQTRGFKTGGTVHIVINNQVGFTISNPLDARSTEYATDVAKM IQAPILHVNGDDPEAVLFVTQLAIDYRMQFKRDVVIDLVCYRRRGHNEADEPSGTQPLMY QQITKQRTTRELYAESLTKAGVVDDARVQAKVDEYRNALDNGLHVVKSLVKEPNKELFVD WRPYLGHAWTARHDTSFDLKTLQELSAKLLEIPEGFVVQRQVAKIYEDRQKMQAGGLPIN WGYAETMAYATLAFEGHPIRMTGQDIGRGTFSHRHAVLHNQKDAGTYIPLQNLYEGQPRF DLYDSFLSEEAVLAFEYGYSTTTPNALVIWEAQFGDFANGAQVVIDQFITSGEHKWGRLC GLTMLLPHGYEGQGPEHSSARLERYLQLCAEHNIQVCVPTTPAQIYHLLRRQVIRPLRKP LVVLTPKSLLRHKLAISTLEDLADGSFQTVIPEIDALDAAKVTRLVLCSGKVYYDLLEKR RAEGREDIAIVRIEQLYPFPEDDLMEAIAPYTNLTNVVWCQEEPMNQGAWYSSQHHLRRS IGNHNKALGLEYAGRDASAAPACGYASMHAEQQEKLLQDAFTV