Protein Info for GFF1741 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14696: Glyoxalase_5
  • amino acids 16 to 164 (149 residues), 212.9 bits, E=2.9e-67
• TIGR01263: 4-hydroxyphenylpyruvate dioxygenase
  • amino acids 24 to 371 (348 residues), 384.4 bits, E=3.5e-119
• PF00903: Glyoxalase
  • amino acids 181 to 291 (111 residues), 36.9 bits, E=6.8e-13

Best Hits

KEGG orthology group: K00457, 4-hydroxyphenylpyruvate dioxygenase [EC: 1.13.11.27] (inferred from 84% identity to ctt:CtCNB1_4246)

Predicted SEED Role

"4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)" in subsystem Aromatic amino acid degradation or Homogentisate pathway of aromatic compound degradation or Plastoquinone Biosynthesis or Tocopherol Biosynthesis (EC 1.13.11.27)

MetaCyc Pathways

• L-tyrosine degradation I (4/5 steps found)
• plastoquinol-9 biosynthesis I (1/3 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
• vitamin E biosynthesis (tocopherols) (1/7 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.27

Use Curated BLAST to search for 1.13.11.27

Protein Sequence (373 amino acids)

>GFF1741 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNTPLPTAAQTAATTWENPMGTDGFEFIEYAAPDPVAMGALFERMGFKAIAKHRHKAVTL
YRQGEINFIINAEPDSFAQRFARLHGPSVCAIAFRVADAKAAYERAISLGAWGYAQSAGP
GELNIPAIKGIGDSIIYFIDKWRGKNGAKTGDIGNIGFFDVDFEPLPGAELNPVGHGLTY
IDHLTHNVHRGRMEEWAGFYERLFNFREVRYFDIEGQATGVKSKAMTSPCGKIRIPINEE
GNEKSGQIQEYLDRYHGEGIQHIAMGSTNLYDTVDALELSGVKLLNTSETYYELLPKRIP
NHGEDLEALKQRNILVDGAPGELLLQIFSENQLGPIFFEFIQRKGNQGFGEGNFKALFET
MELDQVRRGVLKA