Protein Info for GFF167 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1166 transmembrane" amino acids 22 to 46 (25 residues), see Phobius details amino acids 183 to 206 (24 residues), see Phobius details PF05227: CHASE3" amino acids 46 to 178 (133 residues), 135.3 bits, see alignment E=4.2e-43 PF13185: GAF_2" amino acids 253 to 387 (135 residues), 47.9 bits, see alignment E=5e-16 PF01590: GAF" amino acids 260 to 386 (127 residues), 26.9 bits, see alignment E=1.9e-09 PF00512: HisKA" amino acids 487 to 554 (68 residues), 65.8 bits, see alignment 8.7e-22 PF02518: HATPase_c" amino acids 602 to 712 (111 residues), 100.3 bits, see alignment E=2.6e-32 PF00072: Response_reg" amino acids 775 to 882 (108 residues), 61.7 bits, see alignment E=2.1e-20 amino acids 898 to 1008 (111 residues), 63.1 bits, see alignment E=8.1e-21 amino acids 1044 to 1156 (113 residues), 101 bits, see alignment E=1.4e-32

Best Hits

KEGG orthology group: None (inferred from 52% identity to bph:Bphy_4210)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1166 amino acids)

>GFF167 Two-component system sensor histidine kinase (Variovorax sp. SCN45)
MNTPSAIDPEDFDRLLSRNLKLPLIGGVFGAVVFVGLILFLLNTIGWVEHTDRVTRAASE
LQRQSIDMETGMRGFLITGDETFLEPYQSALPRMKTDTAALRELVSDNRQQVERLDRIAA
IQGTWIEFARSLIAARRAGEDAQAQVRLGRGKRLTDDMRAEFTAFIDTEQALRFQRNNDA
NRTAWWVICLFLLFTLTLTGLVAYFGRRQLMRLSESYDAVLKEQAAHTDRLSHEAWLRGA
QTELVGELVGELSAPDMGRKILAFFSRHLGTSVGAMYVRERHGPLRRASSYGFSSAAEAT
PQVFSPTESLVGQAAAERRRMVIEPVTADYLKVNSGLGEMTPQAVLLLPVASDGMVNGVI
ELGLPGALDERGSQLLDVVADDIGSSLAAARYREQLQDVLAETQQLNEELQVQQEELRTA
NEELEEQSRALRASQAMLENQQAELEQTNSQLSERTEALDQRNTALRRVQRDLEDRADEL
QRASRYKSEFLANMSHELRTPLNSALILAKLLGDNPQGNLSPEQVKFAESIYSSGNDLLV
LINDILDISKVEAGKLEVVPEDVPLRRLAESLETTFRPLAMQKNLSFRLDIRPDAPGSLV
TDSQRVEQILKNLLSNALKFTDRGEVALVVSGTADGGAAFAVSDSGIGIDPQQHELIFEA
FRQADGTTSRRYGGTGLGLSISRDLTQLLGGTLAVQSQPGQGSTFVLQLPAKAPQASGNA
SATQSPIYTPKPAHAPVGQAPAAPATPLAPQPPSPVPAPQFADDRSLPRDQVRRVLVIED
EPQFAHILYDLAHELGYRCLVAHGAADGFELATQFVPDAILLDMRLPDSTGLDVLQRLKD
SPHTRHIPIHVVSAADNAQGAALQMGAIGYALKPTTRDELMRVFARLEDKLTQKVKVVLL
VEDDDLQRESVMRLIEDDDIEIVAVGSGEEALELLRTRVFDCMITDLRLPDMQGSDLLKA
MAAEEIVSFPPVIVYTGRNLTRDEETELQRYSRSIIIKGARSPERLLDEVTLFLHKVEAE
LSSERQGMLKTARGRDRIFEGRTILLVDDDVRNIFALTSALEQRGAAVEIGRNGREALEK
LDQVREIDLVLMDVMMPEMDGLEATRRMRADPRFEKMPVIAITAKAMKDDREQCLAAGAN
DYLAKPVDLERLFSLLRVWMPKMERL